• LIving Near Fields Increases Pesticide Exposure
  • Grow a Lush Garden Organically
  • Learn to Keep Insects Out of your Crops
  • Learn About Pesticides in Foods
  • SNAP Display at Event
  • Weeds Can Be Managed Without Chemical Pesticides
  • Driving Near Recently Sprayed Fields Exposes People to Pesticides
  • SNAP Tour of Organic Vegetable Garden
  • Learn To Manage Weeds Without Chemical Pesticides
  • Link to SK Organic Resources

Nervous System Effects

Attention Deficit/Hyperactivity Disorder (ADHD)

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Pyrethroid Pesticide Use Increases Rates of ADHD in Adolescent Boys in New Study (Beyond Pesticides June 4, 2015). "Boys with detectable urinary 3-PBA, a biomarker of exposure to pyrethroids, are three times as likely to have ADHD compared with those without detectable 3-PBA. Hyperactivity and impulsivity increased by 50 percent for every 10-fold increase in 3-PBA levels in boys". The use of pyrethroids has also "been linked to learning problems, and adverse behavioral and emotional development in children". 

Attention-Deficit/Hyperactivity Disorder and Urinary Metabolites of Organophosphate Pesticides. Maryse F. Bouchard et al , Pediatrics; originally published online May 17, 2010. Children with more organophosphates marker in their urine (especially dimethyl alkylphosphate (DMAP)) were more likely to be diagnosed as having ADHD. These findings support the hypothesis that organophosphate exposure, at levels common among US children, may contribute to ADHD prevalence.

Autism and Developmental Delays in Children

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Aerial Mosquito Spraying Linked to Elevated Autism Rates  (Beyond Pesticides, June 15, 2017) Communities exposed to frequent aerial spraying for mosquito control experience elevated rates of autism diagnoses, according to new research. The study identifies the frequent use of synthetic pyrethroid insecticides, which are linked to neurocognitive and behavioral impacts, among other health effects...The study finds that the zip codes with frequent aerial pyrethroid exposure are 37% more likely to have higher rates of childhood developmental delays and autism spectrum disorder. The researchers acknowledge that the study establishes a correlational, not a causal, link between pyrethroid exposure and autism/developmental disorders, it adds to a growing body of research demonstrating an exposure-effect relationship between the two.

Banned Chemicals Linked to Increased Autism Risk (Beyond Pesticides, August 24, 2016) Researchers at Drexel University report that higher levels of some organochlorine compounds during pregnancy are associated with autism spectrum disorder (ASD) and intellectual disability (ID). The organochlorine compounds under study have long been banned in the U.S., and include pesticides like DDT, underscoring how pervasive and persistent these chemicals are, and their continued impact on human health. The research is reported in the study Polychlorinated Biphenyl and Organochlorine Pesticide Concentrations in Maternal Mid-Pregnancy Serum Samples: Association with Autism Spectrum Disorder and Intellectual Disability, 

Autism risk higher near pesticide-treated fields, study says Exposure of pregnant women to organophosphates and also for the first time to pyrethroids linked to autism risk. The study also reported an increased risk of developmental delays, but not autism, in kids whose moms lived near fields where carbamates, including methomyl and Sevin, were applied. Good review of autism risks to put those in perspective. June 23, 2014 

Autism Explained: Synergistic Poisoning from Aluminum and Glyphosate - Stephanie Seneff. Video (2 hours 8 minutes) May 28, 2014

Brain Damage

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Study Reveals: Organophosphate Pesticides Cause Lasting Damage to Brain and Nervous System (Beyond Pesticides, December 10, 2012)   Low-level exposure had significant detrimental effect on working memory and information processing

Pesticides may damage brain     (October 24, 2008. sources: Globe and MailPANNA) Children are especially at risk. Pesticides that could be damaging included organophosphates (OPs), carbamatespyrethroidsethylenebisdithiocarbamates and chlorophenoxy herbicides (such as 2,4-Dmecoprop and dicamba commonly used on lawns)

 Pesticide Exposure Damages Nervous System, Brain and gastro-intestinal tract .(July 2006)

Brain Inflammation

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Inhaled Pollutants May Inflame More Than the Lungs (2010)  

(By Janet Raloff, Science News, Web edition: May 7, 2010, Print edition: May 22, 2010; Vol.177 #11 (p. 16)) 

Scientists have known that air pollution can impair airways and blood vessels. The emerging surprise is what it might do to the brain. Increasingly, studies have been highlighting inflammation-provoking nanopollutants as a potential source of nerve cell damage. PAULE's NOTE: Research into Multiple Chemical Sensitivities has long indicated that pollutants crossed the blood-brain barrier. It has also shown through SPECT and other brain scans that areas of the brain can shut down upon exposure to substances one is sensitive to, In other words, blood circulation to the brain would be shut down or reduced for hours at a time. Research in nano-particles has recently shown that they are small enough to enter cells. In the meantime, other research indicated that it's not only the size of a particle that is important but also what it is. Pesticide applications often produce very small particles in the nano-particle range. Nothing surprising for those of us who have MCS and have been following the research. I am however horrified to see these measurable effects widespread to all children exposed to polluted air. Full article:  http://www.sciencenews.org/view/feature/id/58906/title/Destination_brain. Information accessible to paid subscribers only.Try accessing a library. 

 

Parkinson's Disease

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see also Exposure to Pesticides linked to ALS (Beyond Pesticides, May 16, 2016), pesticides in food and glyphosate

Parkinson's linked to gut bacteria  (Robert Ferris, CNBC, 1 December 2016) The scientists published their findings Thursday in the journal Cell. 'The germ-free mice were still overproducing alpha-synuclein, but their brain cells were not accumulating the protein. The germ-free mice showed fewer symptoms and performed better on a series of motor skills tests meant to model the kinds of tests given to human patients.' More experiments determined that what gut flora produces affects the development of Parkinson's. SNAP Comments: Several pesticides and other toxins have been linked to Parkinson's in the past. Now we also know from research that some pesticides, including glyphosate, affect the health of gut bacteria, usually suppressing good flora and promoting bad. The effects of a pesticide on gut flora are not required tests for pesticide registration. Of course use of antibiotics and what one eats is also important, but remember that people eating conventional food ingest several pesticides on a daily basis. Evidence is accumulating that gut flora is extremely important to the maintenance of health and the development of many diseases. I sincerely hope that more pesticide and toxins regularly found in our environment start being tested for their effect on gut flora. That research would provide a mechanism of action.

Pesticides and Parkinson's: Further Proof of a Link  Jan. 3, 2013. UCLA researchers have discovered a link between Parkinson's and the pesticide benomyl, whose toxicological effects still linger some 10 years after the chemical was banned by the U.S. EPA and Canada...A new pathway was discovered. The pesticide prevents an enzyme called ALDH (aldehyde dehydrogenase) from keeping a lid on DOPAL, a toxin that naturally occurs in the brain. Benomyl was widely used in the U.S. for three decades until toxicological evidence revealed it could potentially lead to liver tumors, brain malformations, reproductive effects and carcinogenesis. It was banned from the US in 2001 and at the end of 2003 in Canada.

Agent Orange Tied to Parkinson’s in Vietnam Vets (July 2009)

Occupational Use of 2,4-D, Permethrin Triple the Risk of Parkinson’s Disease   (Beyond Pesticides, Sept.16,2009)

Gene Variants and Pesticide Exposure Increase Risk of Parkinson’s Disease   (Beyond Pesticides, January 11, 2010) The findings show that study participants with two copies of gene variant have a significantly increased risk of developing Parkinson’s disease when exposed to certain organophosphate pesticides used in agriculture...Individuals with the variant MM PONI1-55 genotype that are exposed to organophosphates exhibit more than twice the risk of Parkinson’s disease compared to carriers of wildtype or heterozygous genotype and no exposure. ( diazinon, chlorpyrifos)

New evidence linking pesticides, genes & Parkinson's (PanUps,  May 14, 2009) "Exposure to commonly used agricultural pesticides may increase the risk of developing Parkinson's disease, particularly among people who have certain gene types," reports Environmental Health News. Summarizing the new research, EHN notes: "The degenerative nerve disease can develop when dopamine levels in the brain are lower than normal. Without pesticide exposures, susceptible gene variants alone were not sufficient to increase risk. The increased risk to Parkinson's required both susceptible genes and pesticide exposure." The full article (PDF) is available from Environmental Health Perspectives.

Residential Exposure to Agricultural Pesticides Increases Risk to Parkinson’s Disease. (Beyond Pesticides, March 16, 2009) Posted in California, Maneb, Paraquat, Parkinson's :exposure to both pesticides within 500 meters of an individual’s home increases the risk of developing Parkinson’s by 75 percent. For individuals 60 years of age or younger at the time of diagnosis, there is a more than four-fold increase in risk of the disease when exposed to a combination of maneb and paraquat

Gene-Pesticide Interactions Linked to Parkinson’s Disease (Beyond Pesticides, March 2, 2009) Posted in Maneb, Paraquat, Parkinson's

Pesticides may be blamed for rise of Parkinson' in Manitoba: Study

Pesticides Trigger Parkinson Disease by Kagan Owens(Pesticides and You. Vol 28, no 1, Spring 2008. Beyond Pesticides, p.14) Many types of insectides are toxic to the nervous system.The better-known classes such as the oganochlorines (OCs e.g. endosulfan), organophosphates (OPs: e.g.malathionchlorpyrifos), the carbamates (e.g. carbofuran), synthetic pyrethroids (e.g. permethrinresmethrin). some herbicides such as 2.4-D are also toxic to the nervous system. This article has a list of specific pesticides linked to Parkinson Disease.

Parkinson's Disease (Beyond Pesticides

also see Childrenfact sheets/chlorpyrifos

Alzheimer's Disease (Beyond Pesticides)

MS and ALS under auto-immune diseases

Lower IQ in children

Motor Neuron Disease  Exposure to Pesticides linked to ALS (Beyond Pesticides, May 16, 2016) 

Others

Brain and Behavioral Effects of Early Exposures to Neurotoxicants  (University of California Television (UCTV), Aug 11, 2015)  There is also a significant link to meaningful tremors and learning deficits. This presentation addresses the impact of prenatal exposure to a common neurotoxicant on brain structure and neuropsychological function in an inner-city cohort of minority children. The toxic chemical, an organophosphate insecticide (chlorpyrifos), has been banned for indoor residential use in the U.S. since 2001, but continues to have widespread application for agricultural purposes. Possible moncholinergic mechanisms involve disruption of neural cell development and neurotransmitter systems, including the formation and activity of synapses in different brain regions. This presentation examines the evidence for long-term effects of prenatal chlorpyrifos exposure on neuropsychological profiles and brain morphology as measured by MRI. Series: "MIND Institute Lecture Series on Neurodevelopmental Disorders" Health and Medicine Professional Medical Education Show ID: 29838

Mothers with High Exposure to DDT More Likely to Have Children with Autism, Study Finds  (Beyond Pesticides, August 22, 2018)   Women tested for DDE and PCBs. "Though this study links autism to long-banned DDT, it raises significant concerns about legacy contamination from this chemical, which remains ubiquitous in the environment and in human bodies."

Mothers with High Exposure to DDT More Likely to Have Children with Autism, Study Finds  (Beyond Pesticides, August 22, 2018) 

women tested for DDE and PCBs "Though this study links autism to long-banned DDT, it raises significant concerns about legacy contamination from this chemical, which remains ubiquitous in the environment and in human bodies."

How the pesticide believed to be killing the bees could be affecting humans (By Nicole Mortillaro Science and Weather Reporter  Global News April 20, 2016) filed under health /links

Neonicotinoid pesticides blamed for bee deaths could affect humans, EU agency says (Alex Ballingall News, Dec 20 2013)  An agency-sponsored study suggested two neonicotinoids, acetamiprid and imidacloprid, might affect a developing human nervous system — that of a fetus or young child — in a way similar to nicotine exposure. The study identifies potential affects on memory, learning ability and motor use, leading the agency to propose lowering the levels of human exposure to the chemicals considered acceptable. 

New Research Confirms Neurotoxicity of Pesticide Synergist PBO (Beyond Pesticides, June 15, 2012) As with many so-called “inert” ingredients, pesticide products often contain five to ten times more PBO than the active ingredient in the formulation. PBO is listed among the top 10 chemicals detected in indoor dust, often a significant route of exposure to children...“We were concerned when our study confirmed that PBO disrupted neurological development pathways – especially given the widespread use of this chemical in American homes,” said Wei Chen, PhD,...

link to SNAP's page on pyrethrins and pyrethroids

Gulf war research indicated that mixing a drug to protect against nerve toxin, DEET for mosquito repellent and pyrethorids sprayed for sand flies in the tents compounded the toxicity many times and caused severe effects  at levels way below what each caused on its own.

Neurotoxicity Resulting from Coexposure to Pyridostigmine Bromide, DEET, and Permethrin: Implications of Gulf War Chemical Exposures. (Mohamed B. Abou-Donia. Journal of Toxicology and Environmental Health. Volume 48, Issue 1, 1996. pages 35-56)

Acute Oral Toxicity Study of Pyridostigmine Bromide, Permethrin, and DEET in the Laboratory Rat.(Wilfred C. McCain Robyn Lee Mark et al.Journal of Toxicology and Environmental Health. Volume 50, Issue 2, 1997. pp pages 113-124)

Combined Exposure to Deet (N,N-Diethyl-m-Toluamide) and Permethrin: Pharmacokinetics and Toxicological Effects. (Aqel W. Abu-Qarea & Mohamed B. Abou-Donia.Journal of Toxicology and Environmental Health, Part B: Critical Reviews.Volume 6, Issue 1, 2003. pages 41-53).