Diamide insecticides, including Cyantraniliprole

also see pesticide drift/research, neonicotinoids p2

Cyantraniliprole and other anthranilic diamide insecticides

Diamide Insecticides 

The following diamides have been given ISO common names.5 Flubendiamide and cyhalodiamide are phthalic 6 diamides5. Chlorantraniliprole, cyantraniliprole, cyclaniliprole, fluchlordiniliprole, pioxaniliprole, tetrachlorantraniliprole, tetraniliprole, and tiorantraniliprole are anthranilic7 diamides.5 Eight diamide insecticides have been commercialized as of February 2023.2

They are especially effective against caterpillars but, 'According to one review, the first species reported to show resistance to diamides was the diamondback moth in 2012.4

The binding of diamides or ryanodine to the calcium channels causes them to remain open, leading to the loss of calcium crucial for biological processes.

Diamides show low acute mammalian toxicity and appear to safe for bees.12

A metabolite of flubendiamide is very persistent and toxic to aquatic invertebrates, causing flubendiamide to be banned by the United States EPA.13'

SNAP Comment: The first one was commerialized in 2007 so there is likely little independent studies. Registered in Canada as of 1 November 2026.:0 Flubendiamide,  0 cyhalodiamide, 45 (from 48) Chlorantraniliprole, 20 (from 21) cyantraniliprole, 3 cyclaniliprole, 0 fluchlordiniliprole, 0 pioxaniliprole, 0 tetrachlorantraniliprole, 9 tetraniliprole, and 0 tiorantraniliprole. 

Today, I saw a YouTube ad for the novel insecticide 'Lumiderm Oniq' for seed treatment of canola for nematodes and flea beetles.

It is related to chlorantraniliprole (20 registered products in Canada). They have a  common mechanism of toxicity which has not been considered. 

The PANNA pesticide database for cyantraniliprole. indicates it is very understudied. There are currently 26 labels registered in the US, seemingly widely used and on a variety of crops (see usage tab), and 19 registered Cyantraniliprole products in Canada. 

Many organizations have expressed concerns about it both in the US and Canada regarding endangered species, water contamination and lack of proper data to evaluated many outcomes. It is a systemic insecticides meaning it spreads to all parts of a plant. It is also 

The following links will open on a separate page. 

Bay Area Clean Water Agencies Comments of draft review of Cyantraniliprole

• If the pesticides reregistration process fails to identify and implement mitigation, an undue burden to address the problem is placed on local governments

Center for Biological Diversity Comments on EPA’s Draft Evaluation for Cyantraniliprole

• inadequate buffers for application drift and run-off,
• presents considerable risk of runoff,
• The available information about the toxicity of CTP is minimal and not protective of chronic exposure to long-lived mollusks.
• Even with a lack of available toxicity studies, the BE shows risk LOC exceedances for acute and chronic exposure and sublethal impacts from CTP include growth inhibition.

Safe Food Matters Comments on Proposed Maximum Residue Limit for CYANTRANILIPROLE Comment on its use on hops specifically but general info.

•  is toxic to aquatic organisms, non-target terrestrial plants, certain beneficialanthropods and bees.
• In 2013, the EPA found that CY is “highly or very highly toxic” to hundreds of endangered species:
• effects of residues of pesticides in soil are harmful but are overlooked in assessments.
• very high Acceptable Daily Intake (ADI) for children under 2 put inn question the reliability. The safety factor of 10 was not applied  (While cchildren should not drink beer, it is much more of a worry for canola oil)
• cancer risk assessment not conducted because of lack of methodology.
• failure to assess whle products and tank mixtures
• excessive proposed MRL (maximum residue limit) 

PMRA- Cyantraniliprole and Ference Insecticide

Pesticide Treadmill Results in Wide Residential Exposure to Newest Toxic Insecticides, Diamides and Neonics      In a study published in Environment International, researchers detect neonicotinoid (neonic) and diamide insecticide contamination in nearly all of the 200 soil samples collected from urban residential areas across ten provinces in China between October and December 2024. Sun Yat-Sen University; Qingdao Binhai University
   They also assess the neurotoxic potential of neonics and diamides as a class, finding that the diamide (e.g., chlorantraniliprole) mixtures show higher neurotoxicity potential despite much lower concentrations relative to the neonicotinoids. As expected, children have higher intake of the chemicals studied than adults.   These findings build on existing evidence of the pesticide drift potential and adverse health effects associated not only with neonicotinoid insecticides, which are replacing organophosphates as some of the most widely used, but also the pesticide family that the industry will likely transition to next as a replacement—diamides.  #neonics #diamide #contamination #neurotoxicity #health #drift #dailynews