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Glyphosate 2

also see wildlife section//birdsglyphosate,  climate changeSafety of Pesticideshealth/cancer/ links. health/cardiovascularmental healthnervous system effectshealth/endocrine disruption, DNA damage and cancer/links 2, Legal/litigation

Loss of Chromosome Y in Male Farmers Genotoxic Implications for Cancer    (Beyond Pesticides, January 3, 2024) A study published in Environmental Health Perspectives finds elevated, chronic exposure to glyphosate throughout one’s lifetime increases the risk of mosaic loss of chromosome Y (loss of chromosome Y occurs to many men in some cells due to aging mLOY) that impacts a noticeable fraction of cells... the risk of mLOY is a biomarker for genotoxicity (the damage of genetic information within a cell causing mutations from chemical exposure, which may lead to cancer) and expansion of cellular response to glyphosate, resulting in the precursor for hematological (blood) cancers. This study is one of the first to identify sex-specific chromosome degradation, with stark evidence demonstrating links to various cancers, including non-Hodgkin lymphoma.   The results find that mLOY is detectable in 21.4 percent of farmers, with mLOY expanding throughout most cells in 9.8 percent of farmers. Most farmers with mLOY expanding throughout most cells are older in age, with a greater lifetime exposure and intensity of exposure to glyphosate. However, these individuals are non-smokers and non-obese, which are other risk factors for mLOY.

Low-Dose Chronic Glyphosate Exposure Increases Diet-Induced Non-Alcoholic Fatty Liver Disease      (Beyond Pesticides, December 21, 2023) A new study published in Environmental Toxicology and Pharmacology adds to prior research indicating glyphosate promotes the occurrence of nonalcoholic fatty liver disease (NAFLD) through diet by causing liver inflammation and oxidative stress. More importantly, the predisposition for NAFLD occurred at levels within toxicological limits, which are doses of glyphosate classified as causing no adverse effects or No Observed Adverse Effect Level (NOAEL).  NAFLD is a condition that causes swelling of the liver and can eventually lead to cirrhosis, cancer, or liver failure.    Health officials estimate about 100 million individuals in the U.S. have NAFLD, with NAFLD being the most common liver disease among children. Cases of NAFLD have doubled over the past 20 years.   However, glyphosate did increase the rate (upregulation) of 212 genes associated with oxidative stress and inflammation in the liver while downregulating 731 genes related to cell division. Mouse study. 

Prenatal and Early Life Exposure to Glyphosate Herbicides Induce Hormonal Effects Disrupting Sleep and Neurodegenerative Diseases    (Beyond Pesticides, December 6, 2023) 'A study published in Antioxidants finds prenatal and early life exposure, usually after birth (perinatal), to glyphosate-based herbicides (GBH) induce oxidative stress in the brain, causing damage and negatively affecting melatonin levels.'     Rat study. 'Researchers analyzed serum melatonin levels and changes in the striatum cells located in the brain among the offspring 90 days after their birth. The results find that serum melatonin levels decrease by 43 percent among adult offspring compared to control offspring. Exposure to GBH also induced oxidative stress in the brain, resulting in changes in the brain’s striatum, including a 45 percent increase in lipid peroxidation, a 39 percent increase in DNA/RNA oxidation, and an increase in protein levels of the antioxidant enzymes like superoxide dismutase, glutamate–cysteine ligase, and glutathione peroxidase.'

Association between urinary glyphosate levels and serum neurofilament light chain in a representative sample of US adults: NHANES 2013-2014    ( An-Ming Yang  et al, J Expo Sci Environ Epidemiol. 2023 Sep 6).This is the first research to suggest an association between glyphosate exposure and biomarkers indicative of neurological damage in general U.S. adults. 

Glyphosate Exposure Linked to Severe Depression and Cognitive Decline in American Adults (Sustainable Pulse, Aug 29, 2023)    'A new peer-reviewed study, published in the journal Environmental Research, has revealed an astonishingly strong link between severe depression, cognitive decline and exposure to the world’s most used herbicide, glyphosate. The study authors stated, "“Our study used a cohort representative of the U.S. adult general population and found a significant negative correlation between urinary glyphosate levels and cognitive function test scores. Additionally, our findings suggest that the odds of having severe depressive symptoms were significantly higher than having no symptoms in individuals with higher glyphosate levels, as measured by the PHQ-9."    Industry has not conducted any long-term neurotoxicity studies on Roundup, the substance that people and animals are actually exposed to. Some other recent independent studies however suggest that both glyphosate alone and glyphosate-based herbicides such as Roundup are neurotoxins.   A toxicological study on rats found that glyphosate depleted the neurotransmitters serotonin and dopamine.'   original article 

Zebrafish Study Links Glyphosate Exposure to Heart Damage Through Aging and Reduced Creation of Cardiac Muscle Cells    (Beyond Pesticides, June 30, 2023) 'Exposure to environmentally relevant concentrations of the herbicide glyphosate (GLY) has the potential to induce heart damage (cardiotoxicity) through the aging (senescence) of cells and a reduction of the number of rapidly increasing (proliferating) cells, according to a study published in Ecotoxicology and Environmental Safety. Specifically, glyphosate induces toxic effects on cardiomyocytes (cardiac muscles) responsible for contractions that pump the blood.' Cardiovascular (heart) disease (CVD) is one of the leading causes of death and disability in the U.S. 

Mapping the key characteristics of carcinogens for glyphosate and its formulations: A systematic review  (Iemaan Rana et al, Chemosphere, 2023. The link goes to ScienceDirect for free access.) New scoping review strengthens glyphosate carcinogen connection claim.

On June 13, 2023, Safe Food Matters returns to Federal Court in its ongoing battle with Health Canada over glyphosate, Canada’s most widely used herbicide.   'Why? Because something’s not right. In February, 2022, the Federal Court of Appeal ordered the PMRA to review our “Notice of Objection” for a second time – and the Court even provided “Guidance” to PMRA on how to address the issues. But PMRA did not follow the Guidance. Even more, PMRA bent over backward to not address the concerns we raised. PMRA rewrote history. PMRA made up totally new legal tests. PMRA reached for rebuttals without evidence. PMRA defied the rules of procedural fairness. It is clear PMRA does not want a review panel, even though the law allows for it.   Watch the Hearing: We would appreciate your support by watching the virtual hearing. It starts at 9:30 am PST, 12:30 EST and is scheduled for the full day. Go to this link for the calendar of hearings for June 13 (link in link), and scroll down to the Ottawa hearing for the case, and select the icon “register for the hearing” which looks like a pen on paper. Our case is Safe Food Matters Inc. v. The Attorney General of Canada and Minister of Health Docket T-2292-22.  Our counsel is Jason Gratl.  The filings for the Motion will be on our website, under Filings for case T-2292-22.'

Poisoning Regulation, Research, Health, and the Environment: The Glyphosate-Based Herbicides Case in Canada   (by Marie-Hélène Bacon et al, Toxics 2023, 11(2), 121; Published: 26 January 2023)  Abstract:   'Glyphosate-Based Herbicides (GBHs) are the most widely used pesticides on the planet as well as in Canada, where a total of almost 470 million kilograms of declared “active” ingredient glyphosate was sold between 2007 and 2018. GBHs accounted for 58% of pesticides used in the agriculture sector in Canada in 2017. While the independent scientific literature on the harmful health and environmental impacts of pesticides such as GBHs is overwhelming, Canada has only banned 32 “active” pesticide ingredients out of 531 banned in 168 countries, and reapproved GBHs in 2017 until 2032. This article, based on interdisciplinary and intersectoral research, will analyze how as a result of the scientific and regulatory captures of relevant Canadian agencies by the pesticide industry, the Canadian regulation and scientific assessment of pesticides are deficient and lagging behind other countries, using the GBH case as a basis for analysis.'

Glyphosate Weed Killers Reduce Crop Yields and Hamper Climate Mitigation Efforts(Beyond Pesticides, February 15, 2023) Finnish study of two separate experiments on the grass Festuca pratensis, an important forage crop grown for grazing animals throughout the world. For all experiments and plot variables, none saw glyphosate use have a positive impact on yield or biomass.   (E)ven among uncut grasses, those grown in glyphosate-sprayed soils showed the lowest root biomass. Chlorophyll content also followed this pattern, with those in the most intensively cut grouping showing the lowest content if also grown in soils where glyphosate was applied.  “This demonstrates a tremendous limitation to the potential carbon binding and storage belowground when soils are polluted by pesticide."

Garden pesticides are contributing to British songbird decline, study finds (Helena Horton, The Guardian, 6 february 2023)   The study was published in the journal ??Science of the Total Environment. 'The experiment, which surveyed 615 gardens in Britain, found 25% fewer house sparrows when glyphosate was used regularly. This is an ingredient found in commonly used herbicide brands such as Roundup or Gallup.   Slug pellets also seemed to have an impact on bird sightings; in gardens where metaldehyde slug pellets were used, house sparrow numbers were down by almost 40%.    Prof Dave Goulson, of the school of life sciences at the University of Sussex, said: “The UK has 22 million gardens, which collectively could be a fantastic refuge for wildlife, but not if they are overly tidy and sprayed with poisons. We just don’t need pesticides in our gardens. Many towns around the world are now pesticide free.”'