• SNAP Tour of Organic Vegetable Garden
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  • Link to SK Organic Resources
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  • Driving Near Recently Sprayed Fields Exposes People to Pesticides
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  • SNAP Display at Event
  • Grow a Lush Garden Organically

Glyphosate 2

Glyphosate p.3

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also see under Food/Pesticides in/ p.3resistance/ resistance to antibiotics, health overview/ links

Glyphosate: Cancer, liver disease, endocrine disruption and other health concerns   (Stacy Malkan, US Right to Know, June 16, 2026)   Glyphosate is the most widely used herbicide worldwide. It is linked to cancer, liver and kidney disease, endocrine disruption, neurotoxicity and many other health concerns.  First patented by the Monsanto Company, glyphosate is now manufactured and sold by many companies in hundreds of products. It is best known as the active ingredient in Roundup-branded herbicides, and the herbicide used with “Roundup Ready” genetically modified organisms (GMOs). More than 90% of GMO corn and soybeans in the U.S. are genetically engineered to tolerate herbicides, according to USDA data.  A 2017 study in JAMA found that Americans’ exposure to glyphosate increased approximately 500 percent since Roundup Ready GMO crops were introduced in 1996. More than 80% of urine samples drawn from children and adults in a 2022 U.S. study contained glyphosate, according to the U.S. Centers for Disease Control and Prevention. Scientists described this finding as “disturbing” and “concerning.”

One of the world’s most popular weedkillers may be fueling deadly superbugs
A widely used weedkiller may be giving dangerous antibiotic-resistant bacteria an unexpected advantage in the fight for survival.   (Science Direct, Source: Frontiers, June 23, 2026)       Researchers found that highly drug-resistant bacteria from hospitals are also resistant to glyphosate, a commonly used weedkiller. The discovery suggests that agricultural herbicides may be helping antibiotic-resistant microbes survive and spread far beyond healthcare settings. Antimicrobial resistance (AMR) contributes to an estimated 1.1 million to 1.4 million deaths worldwide each year.   Based on the findings, the researchers argue that pesticide regulations should take antibiotic resistance into account before products reach the market.

RETRACTED: Cornerstone glyphosate cancer study   Will Health Canada act on compelling evidence of cancers in humans? (Prevent Cancer Now, 3 December 2025)    Glyphosate is by far the most-used herbicide in Canada. It is hard to follow the industry influence, scientific shenanigans and half-truths underlying decades of escalating use of glyphosate herbicide—"Roundup”. The latest blow to the crumbling veneer of scientific "safety" was the RETRACTION on November 28, 2025, of a much-cited study dating back to April 2000. The claim that, “under present and expected conditions of use, Roundup herbicide does not pose a health risk to humans” has echoed among regulators ever since.  This flawed, unethical, industry-influenced study was an early cornerstone to the manufacturer’s contention and the regulators’ conclusions that the pesticide was “safe and effective.”. The RETRACTION article quoted above cites 'oncerns were raised regarding the authorship of this paper, validity of the research findings in the context of misrepresentation of the contributions by the authors and the study sponsor and potential conflicts of interest of the authors', as well as that the carcinogenicity of glyphosate is solely based on unpublished data. SNAP Comment: A perfect example of ghost writers in the industry shenanigans page. 

La concentration d’herbicides dans des lentilles canadiennes dépasse les normes- Herbicide concentration in Canadian lentils exceeds norms (Radio Canada, Novembre 2025)  english follows. (glyhosate)    'Les équipes de La semaine verte et de L'épicerie ont obtenu des données du gouvernement fédéral qui montrent que certains échantillons de lentilles vendues au Canada affichent des taux d'herbicides allant jusqu'à trois fois la limite permise.    La concentration moyenne de résidus d’herbicides décelés dans les lentilles canadiennes testées par le gouvernement fédéral a augmenté de près de 40 % entre 2015 et 2020. En 2020, 14 échantillons en contenaient des quantités qui représentaient jusqu’à trois fois la limite permise, ce qui n’a pourtant pas déclenché de rappel.  Les lentilles canadiennes sont sous le feu des critiques depuis la diffusion d’un reportage à l’émission française Sur le front, le 10 novembre dernier.     Au Canada, la limite maximale de résidus (LMR) de glyphosate pour les lentilles est de 4 parties par million (ppm). Ce seuil est plus de deux fois inférieur à celui de l’Europe. Les limites européennes ont été augmentées en 2012, résultat des pressions de plusieurs industries, dont celle des producteurs canadiens de lentilles. Le Canada est le plus gros producteur et exportateur mondial de cette légumineuse.... les lentilles qui ont subi une mise en conserve présentent beaucoup moins de résidus de pesticides que les lentilles sèches, ce qui suggère que la cuisson a eu un effet sur les résidus de pesticides.'

English   Herbicide average concentration in Canadian lentils increased almost 40% between 2015 and 2020. In 2020, 14 individual samples reached 3 times the allowable limit. There was no product recall. The Canadian MRL is 4 ppm, more than twice the allowable level in Europe. European limits also increased in 2012 because of trade pressures. Canned lentils have much less  glyphosate residues than dry.

Glyphosate p.4

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also see: Terrestrial invertebrates

Scientists in Austria found that a glyphosate based herbicide reduced earthworm reproduction by 56% in a greenhouse study (The Times of India, Aug 13, 2026)  The experiment involved two species with different ways of living in the soil: Lumbricus terrestris, which makes deeper vertical burrows and comes to the surface to feed, and Aporrectodea caliginosa which spends more of its time within the soil itself.   Eight weeks after planting, the vegetation in half of the mesocosms was treated with a lower-than-recommended dose of glyphosate-based herbicide.  Herbicide treatment reduced earthworm casting activity by 46% as well as reproduction. Aporrectodea caliginosa was the species most affected. There is no equivalent study on earthworms in treated agricultiral soils so it is hard to extrapolatethe results of this study. SNAP Comment: Relvant to Canada as the 2 species of earthworms are found here although Aporrectodea caliginosa is a non-native species apparently not present in Saskatchewan. 

also see wildlife section//birdsglyphosate,  glyphosate 2/ and p.3,  climate changeSafety of Pesticideshealth/cancer/ links and links 2, health/cardiovascularmental healthnervous system effectshealth/endocrine disruption, DNA damage and cancer/links 2, immune,  Low Dose Effects, nervous system effects, liver disease,  Legal/litigation,  legal/litigation/glyphosate,  legislation/regulatory/Canada p.2. , issues/forestry /herbicides, pesticides in food p.2, waterPesticides in Water/ Canada, forestry/ herbicides,  Industry Shenanigans/Regulatory and Legal including preemption laws, Bee die off,  wildlife section/mammalsherbicides

Ignoring the Evidence:: Glyphosate, Deer and the Abuse of Power Paperback – May 19 2026NOTE from Rod Cumberland:    The NB story, plus all the connections with Health Canada and Monsanto is here, even the "behind the scenes" weaselling between the NB forest industry and the NB government is in here.   Currently, number 20 on Amazon's "Hot New Releases" in science! https://www.amazon.ca/gp/new-releases/books/956280  The book will be in NB bookstores on June 15. You can order online presently through Amazon, Barnes and Noble or any place you get your books. I am hoping this blows the discussion of glyphosate in Canada WIDE OPEN. Please spread the word through your networks.    Rod

Ignoring the Evidence highlights the journey of Rod Cumberland growing up as the son of a renowned deer hunter in Charlotte County, NB and how he fell in love with both the outdoors, and the white-tailed deer in his younger days. It follows his colorful life growing up in small town NB, the experiences that strengthened him into a person of principle standing up to injustice, following him all the way through his travails through university enroute to becoming the province’s deer specialist. The book uncovers his investigation into dwindling deer numbers across Crown Land in the Province during his tenure at NBDNR. Convinced by the growing evidence that glyphosate spraying was causing dramatic declines in deer food, he embarked on a mission to educate colleagues, government officials and politicians as to the negative impacts, only to become the target of the forestry oligarchy in the province that was highly dependant on the economic benefits from glyphosate use. Rod became embroiled in the battle for the Conservation Forest in the province and watched as political pressure began to impact the debate, and the careers of colleagues and other professionals in the province. As his career shifted to employment at a forestry college, influence from the powerful forest industry affected management at the college and would cause not only a decline of the college programs, but eventually the career of a well-intentioned professional sticking to his morals, values and evidence. “Part memoir, part expose – Cumberland lays out a twisted tale of how power and politics and corrupted science endanger our natural world, and how hard it is to fight back.” – Carey Gillam, investigative journalist and author.

Trump Faces MASSIVE PROTESTS from FORMER SUPPORTERS!!!  22 minutes video about US MAHA (Make America Healthy Again) former Trump supporters demonstrating in favor of action on glyphosate. Apparently Trump signed an executive order in February and submitted an Amicus brief to the Supreme Court to protect glyphosate. Worth watching. 

Glyphosate: Cancer, liver disease, endocrine disruption and other health concerns   (Stacy Malkan, U.S.Right to Know, September 30, 2025) 

New scientific publication confirms glyphosate causes cancer at EU “safe” exposure levels – evidence ignored in EU reapproval (PAN Europe, June 11, 2025)    article includes link to study.     'It shows that long-term exposure to glyphosate and its formulations, even at very low levels equivalent to the EU’s Acceptable Daily Intake (ADI), causes early-onset leukemia in rats. Worryingly, it also reveals a significant increase in multiple other types of tumours (e.g. skin, liver, thyroid, nervous system, ovary, mammary gland, adrenal glands, kidney, urinary bladder, bone, endocrine pancreas, uterus and spleen), providing solid evidence of glyphosate’s carcinogenic potential.      Alarmed by these results, the authors already shared the leukemia data with EU authorities in 2023, ahead of glyphosate’s reapproval. 2 Under EU pesticide law, active substances and products that may cause cancer must not be approved. Yet despite the study’s scientific rigour and relevance, the European Commission and Member States ignored this evidence and renewed glyphosate’s approval for another decade.' also see Multiple Organ Toxicity from Glyphosate and Roundup at Regulatory Relevant Doses 

Bayer CEO Warns that Company May Stop Making Roundup   (Illinois Farm Policy News,April 18, 2025)   ' “Roundup has generated tens of billions of dollars in sales over time for Bayer and Monsanto, the biotech seed giant and developer of Roundup that Bayer acquired in 2018,” Thomas reported. “Bayer currently produces about 40% of the world’s glyphosate, which farmers spray across fields to tame crop-threatening weeds.”     Reuters’ Rachel More reported Thursday that “Bayer is lobbying U.S. states to adjust their regulations in the battle to control costly litigation targeting its herbicide glyphosate but is also prepared for a possible exit from the market, the group’s CEO said on Thursday.”    “In a court filing Friday, Bayer urged the Supreme Court to take up a Missouri case that awarded $1.25 million to a man who developed non-Hodgkin’s lymphoma after spraying Roundup on a community garden in St. Louis,” Lieb reported. “The federally approved label for Roundup includes no warning of cancer. Bayer contends federal pesticide laws preempt states from adopting additional labeling for products and thus prohibits failure-to-warn lawsuits brought under state laws."    “The Supreme Court in 2022 declined to hear a similar claim from Bayer in a California case that awarded more than $86 million to a married couple,” Lieb reported. “But Germany-based Bayer, which acquired Roundup maker Monsanto in 2018, contends the Supreme Court should intervene now because lower courts have issued conflicting rulings.” '   SNAP Comment:  Presumably, this seems to affect all Bayer's production of glyphosate, or is it only US production? .I suspect Bayer's decision will depend on their success or defeat in avoiding responsibility... If Bayer stops producing RoundUp, the manufacturing will likely just be picked up by some other companies.  

Federal Court rules Canada’s approval of glyphosate product unreasonable  (EcoJustice, 20 February 2025)    'In its decision, the Court noted that Health Canada’s 2022 conclusions that glyphosate-based pesticide products continued to pose acceptable risks was unsubstantiated by any scientific analysis. The Court set aside the renewal of the product, giving Health Canada six months to make a new decision on the renewal that transparently addresses new science on glyphosate risks.   After the hearing of the judicial review, an access to information request revealed that Health Canada planned a review of new glyphosate science in 2022 but proceeded to renew approvals for glyphosate products without completing this review. The planned review was not disclosed to the Court or the public.    A new report from Ecojustice reveals that Canada is now the fifth largest user of pesticides in the world, with sales increasing a staggering 47 per cent in just a decade. These pesticides pose potential harm to the health of humans and the environment.'

Global Glyphosate Study Reveals Glyphosate-Based Herbicides Cause Leukemia in Early Life  (The Ramazzini Institute / October 25, 2023)    In this long-term study, glyphosate alone and two commercial formulations, Roundup BioFlow (MON 52276) used in the EU and Ranger Pro (EPA 524-517) used in the U.S., were administered to rats via drinking water beginning in prenatal life, at doses of 0.5, 5, and 50 mg/kg body weight/day. These doses are currently considered safe by regulatory agencies and correspond to the EU Acceptable Daily Intake (ADI) and the EU’s No Observed Adverse Effect Level (NOAEL) for glyphosate.      About half of the leukemia deaths seen in the rats exposed to glyphosate and glyphosate-based herbicides occurred at less than one year of age. By contrast no cases of leukemia have been observed below one year of age in more than 1600 sprague-dawley rats studied over the past two decades by the U.S. National Toxicology Program (NTP) and the Ramazzini Institute.”     Study Information, including FAQs:at the link    SNAP Comment: neither of the two formulations tested is registered in Canada, or might be under another name. Howver, it seems like glyphosate by itself was also linked to leukemia.

Glyphosate Product: Safe Food Matters and others in Court on Wednesday   This fight is about the product “Mad Dog Plus”, and the fact that the Pest Management Regulatory Agency (PMRA) routinely renews products, on a 5 year basis, without looking into new science on risks arising after major registration decisions.    SNAP Comment: In Canada, a pesticide is re-registered  every 5 years and re-evaluated eveyr 15 years, in theory. Historically, the re-evaluation process has often been far behind. I think new research  only has to be considered in re-evaluations. Even then,  the issue is deeper than that: independent studies are consistently not given the same weight as inadequate industry mandated studies and considered irrelevant. Will this precedent European decision help us?  PAN successfully challenges pesticide product authorisation - major implications  (PAN Europe, January 20, 2025) 

Study reveals lasting effects of common weed killer on brain health  Findings indicate glyphosate exposure increases risk of neurodegenerative disease (By Richard Harth , Arizona State University Newa, December 04, 2024)     The study tracked both the presence and impact of glyphosate’s byproducts in the brain long after exposure ends, showing an array of persistent, damaging effects on brain health.  Glyphosate exposure also resulted in neuroinflammation, Alzheimer’s-like symptoms, and premature death and anxiety-like behaviors, replicating others studies.   The researchers tested two levels of glyphosate exposure: a high dose, similar to levels used in earlier research, and a lower dose that is close to the limit used to establish the current acceptable dose in humans. Furthermore, the scientists discovered these symptoms persisted long after a six-month recovery period in which exposure was discontinued.  This lower dose still led to harmful effects in the brains of mice, even after exposure ceased for months. While reports show that most Americans are exposed to glyphosate daily, these results show that even a short period could potentially cause neurological damage. Link to earlier ASU research that demonstrates a link between glyphosate exposure and a heightened risk for neurodegenerative disorders. The earlier study showed that glyphosate was able to cross the blood-brain barrier.

Glyphosate Mixtures Show Lethal and Sublethal Effects to Embryos, Highlights Regulatory Deficiencies   (Beyond Pesticides, November 13, 2024) A study in Chemosphere, conducted by researchers from the Institute of Biochemistry and Molecular Biology in Germany, reveals the varied lethal and sublethal effects of different glyphosate mixtures through tests on the South African clawed frog, Xenopus laevis (X. laevis). After exposing embryos to four glyphosate formulations, mortality, morphological defects, altered heartbeat rate, and impaired heart-specific gene expression are observed.    The formulations consist of varying concentrations of the active ingredient glyphosate, as well as other active and inert ingredients. such as 10–20% d-glucopyranose,  1–5% N–N-dimethyl-C12-C14-(even numbered)-alkyl-1-amines, 1–10% isopropylamine, 1–3% lauryl dimethyl betaine, 0.25–1% dodecyl dimethylamine. Kyleo only lists the active ingredients glyphosate (27.9%) and 2,4-D (32%).”      All solutions were prepared with glyphosate concentrations of 0.01, 0.1, 1, 10, and 100 mg/L. “The exposure of embryos to 0.01–10 mg/L glyphosate reflects environmentally relevant concentrations already measured in different countries, with 100 mg/L glyphosate representing ‘worst-case’ scenarios (e.g., incorrect handling or improper disposal), but already measured in water bodies in Argentina,” the researchers state.'   The high glyphosate levels caused high mortality. Exposure to 0.1 mg/L glyphosate altered gene exoression in various ways depending on the formulation. 'The different formulations selected for exposure experiments showed varying degrees of lethal effects at the same concentrations of the active ingredient glyphosate,” the researchers summarize. With the varied results, the authors hypothesize that the other ingredients play a role in toxicity.'

One of World’s Largest Dementia Clusters in Young People May Be Tied to High Blood Levels of Glyphosate  (Beyond Pesticides, September 3, 2024)    This article details the saga of getting to the bottom of New Brunswick cluster of neurological disease cases.   Enough evidence to get federal money to investigate but  'the investigation of the potential cluster and its possible explanations was rapidly derailed by intergovernmental turf wars in which one combatant was determined to make the problem go away. Within 20 months of the federal investigative study startup, the project was shut down by provincial authorities.'  Certainly worth a read.

Bayer push to block lawsuits (The New Lede, 11 July 2024)    'In an effort to block further litigation, the chemical giant has turned its focus to getting federal and state legislation passed to block Roundup users from suing the company for damages. According to a recent Washington Post article, Bayer helped draft language for a legislative measure that would limit the types of lawsuits brought by the Roundup users. That measure is included in the US House of Representatives version of the 2024 Farm Bill, which is slated to be finalized later this year. The company has also been pushing lawmakers in several states to pass similar measures.      Key to Bayer’s messaging to legislators is that, because glyphosate is EPA-approved, research showing its harms should be rejected. But the process by which the EPA approved glyphosate decades ago has never been reassuring to independent scientists such as myself. EPA scientists conducting initial assessments of glyphosate in the 1980’s discovered several mice dosed with the pesticide developed rare kidney tumors, prompting the scientists to confirm the pesticide’s link to cancer.     Then the EPA’s pesticides office did what it often does: It ignored the troubling research and the recommendation of its own scientists and approved the pesticide without acknowledging its documented link to cancer.      Even the EPA’s subsequent assessments and reapprovals of the pesticide, required every 15 years, have been plagued by questionable science. In 2022 a federal appeals court ruled that the agency’s finding that glyphosate has no link to cancer violated its own Cancer Guidelines and “was not supported by substantial evidence.”       SNAP Comment:  I find the conclusion 'The disturbing revelation that consumers simply cannot trust that a pesticide is safe simply because it gets the EPA’s stamp of approval.' is made by someone who does not know the history. It used to be a stated part of regulatory agencies policy (including the Canadian PMRA) that registration was not equivalent to safety because pesticides were designed to kill... The regulatory approach has been to reduce concentration and rate  or frequenccy of application and set up some type of safety factor rather than ban a substance. None of these approaches have been showln to be sufficient to reduce risk. That is why many pesticides have finally been banned. 

filed under Industry Shenanigans/Regulatory and Legal including preemption laws and glyphosate 2

Toxic Effects of Glyphosate on the Nervous System: A Systematic Review   (by Carmen Costas-Ferreira et al, International Journal of Molecular Science, 21 April 2022)   The information provided indicates that exposure to glyphosate or its commercial formulations induces several neurotoxic effects. It has been shown that exposure to this pesticide during the early stages of life can seriously affect normal cell development by deregulating some of the signaling pathways involved in this process, leading to alterations in differentiation, neuronal growth, and myelination. Glyphosate also seems to exert a significant toxic effect on neurotransmission and to induce oxidative stress, neuroinflammation and mitochondrial dysfunction, processes that lead to neuronal death due to autophagy, necrosis, or apoptosis, as well as the appearance of behavioral and motor disorders. The doses of glyphosate that produce these neurotoxic effects vary widely but are lower than the limits set by regulatory agencies. ... it is unequivocal that exposure to glyphosate produces important alterations in the structure and function of the nervous system of humans, rodents, fish, and invertebrates.

Campaign calls on province to ban glyphosate spraying     Use of herbicide in Northern Ont. forests impacts wildlife and threatens human health, say Anishinabek critics   (by Jim Moodie, Sudbury Star,  Aug 19, 2024)     'Since glyphosate has been applied as an aerial herbicide, elders “have observed dramatic changes in moose, deer, muskrat and other forest life, as jack pine plantations began replacing mixed forests,” according to the release.      Together, the opponents of the herbicide spraying assembled a petition counting more than 300,000 signatures.    Gelinas noted Quebec actually has far more hydro infrastructure than Ontario, exporting its power to the U.S. as well as domestically, but their utility is still profitable, without relying on the chemical. Meanwhile 'umerous First Nations people are employed to clear brush manually from transmission lines.'

New Glyphosate studies find risks with “on-label” preharvest use (Safe Food Matters, 5 September 2024)     'Preharvest use of glyphosate on malting barley “should not be a recommended practice”, according to the conclusion of a recent field trial report, because it risks “the quality and residue status” of the grain.   The study was conducted to assess preharvest use on barley at different rates and stages of crop maturity. The unexpected finding was that maximum residue limits (MRLs) of glyphosate were exceeded, “even when glyphosate was applied at the recommended level … and time”. In other words, even when spray label directions were followed.'     Pre-harvest use is currenetly banned in Europe. 

Most of the glyphosate in European rivers may not come from farming, researchers suggest  (by Universitaet Tübingen, Phys Org, 26 July, 2024)     In Europe, the seasonal water concentrations of glyphosate in water were mostly constant and not related to pattern of use.  'Initial laboratory tests have now been completed and confirm the hypothesis of glyphosate formation in wastewater treatment plants from this laundry additive.' (aminopolyphosphonates). 'However, there is also some good news: "We do not see glyphosate formation when we simulate conditions directly in the washing machine." '   'The situation in the U.S. is different from that in the EU; concentration patterns of glyphosate in U.S. river water closely follow those of other herbicides, indicating a dominant agricultural input. In contrast to Europe, aminopolyphosphonates are hardly used in the U.S. in laundry detergents.'   SNAP Comment: This illustrates the problem of using sewage sludge to grow food, a widely accepted practice.

Le glyphosate affecterait la réponse immunitaire montre une étude (Radio-Canada, 21Mai 2023)   Healthy tissue degradation?    "The herbicide #glyphosate alters the functioning of the human immune system, according to a new Quebec study. #Autoimmune disorders may appear after prolonged exposure. »."As a reminder: Glyphosate is the best-selling herbicide in the world." Between 1994 and 2014, the amounts used annually increased from 16 million kilograms to 79 million kilograms. Glyphosate and its metabolites can be detected in 80% of the population. They are found in many organs, in human blood and milk. The body eliminates these products in 48 hours, but we continuously ingest them through our diet. »

Gluten-Free Food Test Results (posted by Zen Honeycutt, Moms Across America, 10 June 2024)     This article also presents a summary of results, gluten content regulatory levels and that, "across the board, the samples are extremely low in each mineral based on the FDA Recommended Daily Values and accurate serving sizes per category". Results of glyphosate and pesticides:

  • 44 out of 46 of the samples came back positive for glyphosate.
  • Out of the 237 pesticides we tested for, glyphosate was the most prevalent.
  • Not all of the gluten-free products that were also organic were the lowest in glyphosate.
  • 21% of the samples were positive for glyphosate at levels higher than 10 ppb, the EU threshold for acceptable glyphosate residues.
  • According to Don Huber, Purdue University Emeritus and plant pathologist of 60 years, exposure to .1 ppb of glyphosate is harmful and should be avoided. 95.6% of the samples contained higher than .1 ppb of glyphosate.
  • 100% of the samples contained trace levels or higher of pesticides. 7 samples (15%) contained only trace levels.

The highest level of glyphosate in gluten-free food tested was in Banza Chickpea pasta. 2,4-D was the second most prevalent pesticide. SNAP Comment: US study. Not all brands are present in Canada and if one eats these alternative products, one may need an additional mineral supplement.

Digging deep into herbicide impact on forest ecosystems (UNBC Stories, 12 February 2024)          Ecosystem Science and Management Associate Professor Dr. Lisa Wood has garnered an Alliance Society grant ... to lead a five-year project aimed at better understanding the extent of the impact of glyphosate-based herbicides on forest systems.       While consistently finding glyphosate residues in forest plants in past studies, Wood and her collaborators have also documented a reduction in forest foods for wildlife, changes in the chemistry of residual foods present after treatment and they’ve noted how environmental conditions such as temperature and photoperiod impact residue breakdown. Building on that body of work, this new project will delve into if, and how, changes to forest vegetation influence the health of wildlife at different levels in the food chain.     “We’re focusing on how GBH influences gut bacteria and hormones in organisms in the ‘wild’ forest food web, which is a new direction as previous studies of this type have been conducted in more controlled settings.”

Loss of Chromosome Y in Male Farmers Genotoxic Implications for Cancer    (Beyond Pesticides, January 3, 2024) A study published in Environmental Health Perspectives finds elevated, chronic exposure to glyphosate throughout one’s lifetime increases the risk of mosaic loss of chromosome Y (loss of chromosome Y occurs to many men in some cells due to aging mLOY) that impacts a noticeable fraction of cells... the risk of mLOY is a biomarker for genotoxicity (the damage of genetic information within a cell causing mutations from chemical exposure, which may lead to cancer) and expansion of cellular response to glyphosate, resulting in the precursor for hematological (blood) cancers. This study is one of the first to identify sex-specific chromosome degradation, with stark evidence demonstrating links to various cancers, including non-Hodgkin lymphoma.   The results find that mLOY is detectable in 21.4 percent of farmers, with mLOY expanding throughout most cells in 9.8 percent of farmers. Most farmers with mLOY expanding throughout most cells are older in age, with a greater lifetime exposure and intensity of exposure to glyphosate. However, these individuals are non-smokers and non-obese, which are other risk factors for mLOY.

Low-Dose Chronic Glyphosate Exposure Increases Diet-Induced Non-Alcoholic Fatty Liver Disease      (Beyond Pesticides, December 21, 2023) A new study published in Environmental Toxicology and Pharmacology adds to prior research indicating glyphosate promotes the occurrence of nonalcoholic fatty liver disease (NAFLD) through diet by causing liver inflammation and oxidative stress. More importantly, the predisposition for NAFLD occurred at levels within toxicological limits, which are doses of glyphosate classified as causing no adverse effects or No Observed Adverse Effect Level (NOAEL).  NAFLD is a condition that causes swelling of the liver and can eventually lead to cirrhosis, cancer, or liver failure.    Health officials estimate about 100 million individuals in the U.S. have NAFLD, with NAFLD being the most common liver disease among children. Cases of NAFLD have doubled over the past 20 years.   However, glyphosate did increase the rate (upregulation) of 212 genes associated with oxidative stress and inflammation in the liver while downregulating 731 genes related to cell division. Mouse study. 

Prenatal and Early Life Exposure to Glyphosate Herbicides Induce Hormonal Effects Disrupting Sleep and Neurodegenerative Diseases    (Beyond Pesticides, December 6, 2023) 'A study published in Antioxidants finds prenatal and early life exposure, usually after birth (perinatal), to glyphosate-based herbicides (GBH) induce oxidative stress in the brain, causing damage and negatively affecting melatonin levels.'     Rat study. 'Researchers analyzed serum melatonin levels and changes in the striatum cells located in the brain among the offspring 90 days after their birth. The results find that serum melatonin levels decrease by 43 percent among adult offspring compared to control offspring. Exposure to GBH also induced oxidative stress in the brain, resulting in changes in the brain’s striatum, including a 45 percent increase in lipid peroxidation, a 39 percent increase in DNA/RNA oxidation, and an increase in protein levels of the antioxidant enzymes like superoxide dismutase, glutamate–cysteine ligase, and glutathione peroxidase.'

Association between urinary glyphosate levels and serum neurofilament light chain in a representative sample of US adults: NHANES 2013-2014    ( An-Ming Yang  et al, J Expo Sci Environ Epidemiol. 2023 Sep 6).This is the first research to suggest an association between glyphosate exposure and biomarkers indicative of neurological damage in general U.S. adults. 

Glyphosate Exposure Linked to Severe Depression and Cognitive Decline in American Adults (Sustainable Pulse, Aug 29, 2023)    'A new peer-reviewed study, published in the journal Environmental Research, has revealed an astonishingly strong link between severe depression, cognitive decline and exposure to the world’s most used herbicide, glyphosate. The study authors stated, "“Our study used a cohort representative of the U.S. adult general population and found a significant negative correlation between urinary glyphosate levels and cognitive function test scores. Additionally, our findings suggest that the odds of having severe depressive symptoms were significantly higher than having no symptoms in individuals with higher glyphosate levels, as measured by the PHQ-9."    Industry has not conducted any long-term neurotoxicity studies on Roundup, the substance that people and animals are actually exposed to. Some other recent independent studies however suggest that both glyphosate alone and glyphosate-based herbicides such as Roundup are neurotoxins.   A toxicological study on rats found that glyphosate depleted the neurotransmitters serotonin and dopamine.'   original article 

Zebrafish Study Links Glyphosate Exposure to Heart Damage Through Aging and Reduced Creation of Cardiac Muscle Cells    (Beyond Pesticides, June 30, 2023) 'Exposure to environmentally relevant concentrations of the herbicide glyphosate (GLY) has the potential to induce heart damage (cardiotoxicity) through the aging (senescence) of cells and a reduction of the number of rapidly increasing (proliferating) cells, according to a study published in Ecotoxicology and Environmental Safety. Specifically, glyphosate induces toxic effects on cardiomyocytes (cardiac muscles) responsible for contractions that pump the blood.' Cardiovascular (heart) disease (CVD) is one of the leading causes of death and disability in the U.S. 

Mapping the key characteristics of carcinogens for glyphosate and its formulations: A systematic review  (Iemaan Rana et al, Chemosphere, 2023. The link goes to ScienceDirect for free access.) New scoping review strengthens glyphosate carcinogen connection claim.

On June 13, 2023, Safe Food Matters returns to Federal Court in its ongoing battle with Health Canada over glyphosate, Canada’s most widely used herbicide.   'Why? Because something’s not right. In February, 2022, the Federal Court of Appeal ordered the PMRA to review our “Notice of Objection” for a second time – and the Court even provided “Guidance” to PMRA on how to address the issues. But PMRA did not follow the Guidance. Even more, PMRA bent over backward to not address the concerns we raised. PMRA rewrote history. PMRA made up totally new legal tests. PMRA reached for rebuttals without evidence. PMRA defied the rules of procedural fairness. It is clear PMRA does not want a review panel, even though the law allows for it.   Watch the Hearing: We would appreciate your support by watching the virtual hearing. It starts at 9:30 am PST, 12:30 EST and is scheduled for the full day. Go to this link for the calendar of hearings for June 13 (link in link), and scroll down to the Ottawa hearing for the case, and select the icon “register for the hearing” which looks like a pen on paper. Our case is Safe Food Matters Inc. v. The Attorney General of Canada and Minister of Health Docket T-2292-22.  Our counsel is Jason Gratl.  The filings for the Motion will be on our website, under Filings for case T-2292-22.'

Poisoning Regulation, Research, Health, and the Environment: The Glyphosate-Based Herbicides Case in Canada   (by Marie-Hélène Bacon et al, Toxics 2023, 11(2), 121; Published: 26 January 2023)  Abstract:   'Glyphosate-Based Herbicides (GBHs) are the most widely used pesticides on the planet as well as in Canada, where a total of almost 470 million kilograms of declared “active” ingredient glyphosate was sold between 2007 and 2018. GBHs accounted for 58% of pesticides used in the agriculture sector in Canada in 2017. While the independent scientific literature on the harmful health and environmental impacts of pesticides such as GBHs is overwhelming, Canada has only banned 32 “active” pesticide ingredients out of 531 banned in 168 countries, and reapproved GBHs in 2017 until 2032. This article, based on interdisciplinary and intersectoral research, will analyze how as a result of the scientific and regulatory captures of relevant Canadian agencies by the pesticide industry, the Canadian regulation and scientific assessment of pesticides are deficient and lagging behind other countries, using the GBH case as a basis for analysis.'

Glyphosate Weed Killers Reduce Crop Yields and Hamper Climate Mitigation Efforts(Beyond Pesticides, February 15, 2023) Finnish study of two separate experiments on the grass Festuca pratensis, an important forage crop grown for grazing animals throughout the world. For all experiments and plot variables, none saw glyphosate use have a positive impact on yield or biomass.   (E)ven among uncut grasses, those grown in glyphosate-sprayed soils showed the lowest root biomass. Chlorophyll content also followed this pattern, with those in the most intensively cut grouping showing the lowest content if also grown in soils where glyphosate was applied.  “This demonstrates a tremendous limitation to the potential carbon binding and storage belowground when soils are polluted by pesticide."

Garden pesticides are contributing to British songbird decline, study finds (Helena Horton, The Guardian, 6 february 2023)   The study was published in the journal ??Science of the Total Environment. 'The experiment, which surveyed 615 gardens in Britain, found 25% fewer house sparrows when glyphosate was used regularly. This is an ingredient found in commonly used herbicide brands such as Roundup or Gallup.   Slug pellets also seemed to have an impact on bird sightings; in gardens where metaldehyde slug pellets were used, house sparrow numbers were down by almost 40%.    Prof Dave Goulson, of the school of life sciences at the University of Sussex, said: “The UK has 22 million gardens, which collectively could be a fantastic refuge for wildlife, but not if they are overly tidy and sprayed with poisons. We just don’t need pesticides in our gardens. Many towns around the world are now pesticide free.”'