• SNAP Tour of Organic Vegetable Garden
  • Learn to Manage Pests Naturally
  • Grow a Lush Garden Organically
  • Learn About Pesticides in Foods
  • Learn About Colony Collapse Disorder and How to Protect Bees
  • Learn to Keep Insects Out of your Crops
  • Driving Near Recently Sprayed Fields Exposes People to Pesticides
  • Weeds Can Be Managed Without Chemical Pesticides
  • SNAP Display at Event
  • LIving Near Fields Increases Pesticide Exposure

Liver Disease

also see pesticide fact sheets/malathion, glyphosate, and kidney 

Glyphosate and Roundup proven to disrupt gut microbiome by inhibiting shikimate pathway (GM Watch, 11 December 2019) 'The study found certain adverse effects at all doses tested, disproving regulators' assumptions that these levels have no adverse effects.' SNAP Comment: Note the huge variation in study dosage, based on regulatory acceptable levels. Clearly, glyphosate and Roundup are not 'safe' at levels considered acceptable daily intake or 'no adverse effects'. Interesting that in most pesticide studies there are liver and/or kidney effects. After all, these organs are two of the main detoxification organs in the body. The issue with our 'dose makes the poison' based regulatory system is that we then divide the dose causing problems by 1000 or something then assume it's OK at that level. This is clearly 'baloney'. 'However, proof that glyphosate herbicides can inhibit the EPSPS enzyme and the shikimate pathway in gut bacteria has been lacking. But a new study has proven beyond doubt that this does indeed happen. The study in rats has found that Roundup herbicide and its active ingredient glyphosate cause a dramatic increase in the levels of two substances, shikimic acid and 3-dehydroshikimic acid, in the gut, which are a direct indication that the EPSPS enzyme of the shikimic acid pathway has been severely inhibited. In addition, the researchers found that both Roundup and glyphosate affected the microbiome at all dose levels tested, causing shifts in bacterial populations. For the study, female rats (12 per group) were fed a daily dose of either glyphosate or a Roundup formulation approved in Europe, called MON 52276Glyphosate and Roundup were administered via drinking water to give a glyphosate daily intake of 0.5 mg, 50 mg and 175 mg/kg body weight per day (mg/kg bw/day), which respectively represent the EU acceptable daily intake (ADI), the EU no-observed adverse effect level (NOAEL), and the US NOAEL.' 'The study also revealed that Roundup, and to a lesser extent glyphosate, damaged the liver and kidneys of the rats, even over the relatively short study period of 90 days' .with little reflected in the blood biochemistry. 'Histopathological (microscopic) examination of the liver showed that the two higher doses of Roundup caused a statistically significant and dose-dependent increase in lesions, fatty liver disease changes, and necrosis (death of tissue). In contrast, none of the control animals showed the same liver effects.'

It's in the weeds: Herbicide linked to human liver disease   (University of California - San Diego, May 2019)    'The results, they found, were significant: Regardless of age, race, body mass index (BMI), ethnicity or diabetes status, glyphosate residue was significantly higher in patients with NASH  (non-alcoholic steatohepatitis, a type of nonalcoholic fatty liver disease or NAFLD),than it was in patients with a healthier liver... The findings, coupled with prior animal studies, said Mills, suggest a link between the use of commercial glyphosate in our food supply, which has increased significantly over the past 25 years, and the prevalence of NAFLD in the United States, which too has been on the rise for two decades.Mills plans to next put a group of patients on an all-organic diet and track them over the course of several months, examining how a herbicide-free diet might affect biomarkers of liver disease.'

Roundup Proven to Cause Liver Disease - Recall Must be Enacted (Moms Across America, Zen Honeycutt,  January 09, 2017)   January 9, 2016 a new study reveals that the weedkiller Roundup causes liver disease in rats after being exposed to doses lower than allowed by the EPA to be present on American food and feed crops. The story was published by Claire Robinson of GMWatch. According to the Liver Foundationat least 30 million people—or one in 10 Americans—now have some form of liver disease.study: Roundup causes non-alcoholic fatty liver disease at very low doses

also filed under glyphosate