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Skin
also see exposure
Genetically Weakened Skin Barrier Allows for Easier Absorption of Toxic Chemicals (Beyond Pesticides, January 21, 2021) (I)ndividuals with genetically weakened skin barrier protection experience higher rates of toxic chemicals (i.e., pesticides) absorption through the skin. Studies provide evidence that filaggrin genetic mutations can exacerbate the impacts of chemicals upon dermal (skin) exposure, causing various skin diseases like dermatitis and other chemical-related effects like asthma and cancer. Filaggrin is a protein that is critical to skin cell structure or epidermal homeostasis. Dermal exposure is the most common pesticide exposure routes, compromising 95 percent of all pesticide exposure incidents. Furthermore, many pesticides contain chemicals that act as sensitizers (allergens). Therefore, it is essential to mitigate direct skin contact with these toxic chemicals and enforce proper application protocol. Researchers find that pesticide levels are two times higher in individuals with FLG null mutations. Therefore, increased chemical absorption can have implications for human health. FLG null mutations are relatively common, especially among people of European descent.