Kidney

also see pesticide fact sheets/malathion, glyphosate,liver disease, cancer/links, children and industry shenanigans

Kids and Kidney Cancer: Implication for Prenatal Pesticide Exposure    (Beyond Pesticides, November 10, 2022) A meta-analysis by the University Alberta Hospital, Edmonton, AB, Canada, adds to the plethora of research linking prenatal (before birth/during pregnancy) pesticide exposure to carcinogenic (cancer) tumor development. The analysis, published in Human & Experimental Toxicology, finds parental exposure to pesticides during the preconception (before pregnancy) or pregnancy period increases the risk of Wilms’ tumor (a type of kidney cancer) occurrence among children.    The report also examines occupational versus residential exposure and before-birth (prenatal) versus after-birth (postnatal) exposure. These results strengthen the finding that parental pesticide exposure before or during pregnancy correlates with increased risk for Wilms’ tumor in a child. The IRAC/WHO monographs support this conclusion and policies to stop specific pesticide use to prevent future cases of cancer. The study concludes, “Pesticide exposure in household/residential settings seems to contribute to Wilms’ tumor etiology. 
Acute Kidney Failure Higher Among Farmers: High-Middle-Low Income Countries Suffer Disparities (Beyond Pesticides, August 11, 2022) A study in the International Journal of Environmental Research and Public Health finds that Brazilian agricultural workers are more likely to die from acute kidney failure (AKF) than other acute illnesses. Among the agricultural workers, the prevalence of AKF is higher for individuals at younger ages, who are female, and located in regions south (with increased chemical use), particularly rural areas. 
Banned Pesticides in Well Water Linked to Declines in Kidney Function (Beyond Pesticides, January 12, 2022) Well water in agricultural regions of Sri Lanka is contaminated with highly hazardous insecticides and associated with a decline in kidney function, according to research published in npj Clean Water this month. Of the wells sampled, 68% were found to contain pesticides. Further, every well where pesticides were detected had at least one pesticide recorded above global drinking water guidelines. The chemicals found were also some of the most toxic pesticides to ever be sold, including the organochlorine insecticides DDT/DDE, propanil, and endosulfan, and the organophosphate diazinon. None of these chemicals are permitted for use in Europe or the United States, and some like endosulfan are being phased out globally through the Stockholm Convention. The study found that individuals reporting drinking well water during their lifetimes had glomerular filtration rate (a measurement of kidney health) that was significantly lower on average (6.7) than other individuals who never drank well water, after accounting for differences in age and sex. SNAP Comment: I don't know of many well water contamination studies in Canada. There are currently no PMRA registered products containing DDT/DDE (down from 55), propanil  (down from 7), endosulfan (down from 16) in Canada and 5 (down from 184)  diazinon products (2 commercial and 3 in ear tags). 
Common Insecticide Malathion Linked to Chronic Kidney Disease (Beyond Pesticides, October 19, 2021) 'Exposure to the insecticide malathion increases risk of developing chronic kidney disease (CKD), according to a study recently published in the International Journal of Environmental Research and Public Health.... Risk was not significantly increased by exposure to the other pesticides studied'.(2,4-D, chlorpyrifos, and 3-PBA, the major metabolite for most synthetic pyrethroid insecticides).   'Despite strong links between malathion and a range of different cancers, EPA deigned the chemical as having “suggestive evidence of carcinogenicity,” not the stronger “likely carcinogen” designation initially proposed by EPA staff.' SNAP Comment: As of 19 October 2021, there are 13 malathion products registered in Canada, 5 of those for domestic use (use by consumers, all for outdoor use only)
Glyphosate and Roundup proven to disrupt gut microbiome by inhibiting shikimate pathway (GM Watch, 11 December 2019) 'The study found certain adverse effects at all doses tested, disproving regulators' assumptions that these levels have no adverse effects.' SNAP Comment: Note the huge variation in study dosage, based on regulatory acceptable levels. Clearly, glyphosate and Roundup are not 'safe' at levels considered acceptable daily intake or 'no adverse effects'. Interesting that in most pesticide studies there are liver and/or kidney effects. After all, these organs are two of the main detoxification organs in the body. The issue with our 'dose makes the poison' based regulatory system is that we then divide the dose causing problems by 1000 or something then assume it's OK at that level. This is clearly 'baloney'. 'However, proof that glyphosate herbicides can inhibit the EPSPS enzyme and the shikimate pathway in gut bacteria has been lacking. But a new study has proven beyond doubt that this does indeed happen. The study in rats has found that Roundup herbicide and its active ingredient glyphosate cause a dramatic increase in the levels of two substances, shikimic acid and 3-dehydroshikimic acid, in the gut, which are a direct indication that the EPSPS enzyme of the shikimic acid pathway has been severely inhibited. In addition, the researchers found that both Roundup and glyphosate affected the microbiome at all dose levels tested, causing shifts in bacterial populations. For the study, female rats (12 per group) were fed a daily dose of either glyphosate or a Roundup formulation approved in Europe, called MON 52276. Glyphosate and Roundup were administered via drinking water to give a glyphosate daily intake of 0.5 mg, 50 mg and 175 mg/kg body weight per day (mg/kg bw/day), which respectively represent the EU acceptable daily intake (ADI), the EU no-observed adverse effect level (NOAEL), and the US NOAEL.' 'The study also revealed that Roundup, and to a lesser extent glyphosate, damaged the liver and kidneys of the rats, even over the relatively short study period of 90 days' .with little reflected in the blood biochemistry. 'Histopathological (microscopic) examination of the liver showed that the two higher doses of Roundup caused a statistically significant and dose-dependent increase in lesions, fatty liver disease changes, and necrosis (death of tissue). In contrast, none of the control animals showed the same liver effects.'
filed under glyphosate, kidney and liver disease

New study finds glyphosate causes disease across several generations (The Organic and non-GMO Report, May 2, 2019) "But writing in the journal Scientific Reports, the researchers say they saw “dramatic increases” in several pathologies affecting the second and third generations. The second generation had “significant increases” in testis, ovary, and mammary gland diseases, as well as obesity. In third-generation males, the researchers saw a 30 percent increase in prostate disease—three times that of a control population. The third generation of females had a 40 percent increase in kidney disease, or four times that of the controls. More than one-third of the second-generation mothers had unsuccessful pregnancies, with most of those affected dying. Two out of five males and females in the third generation were obese."

Kidney, Liver Damage Linked to Chronic, Low-Dose Glyphosate Exposure (Beyond Pesticides, September 1, 2015) 'Levels of exposure tested in the recent study are far below what EPA sets as the maximum contaminate level (MCL) in drinking water throughout the U.S. While rats in the study were chronically exposed to .1 parts per billion Roundup concentrations, EPA allows 700 parts per billion. The agency notes that “some people who drink water containing glyphosate in excess of the MCL over many years could experience problems with their kidneys or reproductive disorders.” ' More on glyphosate.