see also glyphosate p.2 and cancer/links 2

Loss of Chromosome Y in Male Farmers Genotoxic Implications for Cancer    (Beyond Pesticides, January 3, 2024) A study published in Environmental Health Perspectives finds elevated, chronic exposure to glyphosate throughout one’s lifetime increases the risk of mosaic loss of chromosome Y (loss of chromosome Y occurs to many men in some cells due to aging mLOY) that impacts a noticeable fraction of cells... the risk of mLOY is a biomarker for genotoxicity (the damage of genetic information within a cell causing mutations from chemical exposure, which may lead to cancer) and expansion of cellular response to glyphosate, resulting in the precursor for hematological (blood) cancers. This study is one of the first to identify sex-specific chromosome degradation, with stark evidence demonstrating links to various cancers, including non-Hodgkin lymphoma.   The results find that mLOY is detectable in 21.4 percent of farmers, with mLOY expanding throughout most cells in 9.8 percent of farmers. Most farmers with mLOY expanding throughout most cells are older in age, with a greater lifetime exposure and intensity of exposure to glyphosate. However, these individuals are non-smokers and non-obese, which are other risk factors for mLOY.

Glyphosate Breakdown Product, Associated with Oxidative Stress and DNA Damage Among Children    (Beyond Pesticides, April 28, 2022) 'A study in Environmental Research finds that glyphosate’s primary metabolite (breakdown product), aminomethylphosphonic acid (AMPA), induces DNA damage through oxidative stress among subpopulations of primary school children. The results find that AMPA, but not glyphosate, has a positive association with DNA damage via oxidation. Moreover, the metabolites of pyrethroids (3-PBA) and chlorpyrifos (TCPy) are also associated with DNA damage and oxidative stress. Lipid damage from oxidative stress did not occur among these pesticides. However, the results suggest parental education levels influence urinary pyrethroid levels. ...Glyphosate degrades relatively quickly in the environment, between five and 20 days, leaving behind AMPA, which is highly persistent with a half-life of 151 days.  SNAP Comment: As illustrated here, AMPA, the byproduct of glyphosate, persists a lot longer in the environment. This is not a unique case. Not only can degradation byproducts persisit  longer, they can also be more toxic than the original product. Current registration regulations generally overlook the effects of byporducts.

filed under children /glyphosate