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Digestive tract

Human Microbiome

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See also pesticides in food and glyphosate

Pesticide Exposure Alters Bacterial Diversity in the Mouth (Beyond Pesticides, December 6, 2016) A new study released by researchers at the University of Washington, Seattle finds that exposure to organophosphate insecticides is associated with changes in oral bacterial diversity, particularly for exposed farmworkers. The study provides insight into the far-reaching changes pesticide exposure can cause to the human body, which are not captured by current risk assessment models used by the U.S. Environmental Protection Agency (EPA). Although past research has investigated the impact of pesticide exposure on the gut microbiome, this is one of the first studies to look at oral bacterial diversity...Scientists focused on exposure to the organophosphate insecticide Azinphos-methyl (AZM), which at the time of the study (2005-2006) had not begun its cancellation proceedings...Of the farmworkers that have detectable levels of AZM in their blood stream, scientists found “significantly reduced abundances of seven common taxa of oral bacteria, including Streptococcus, one of the most common normal microbiota in the mouth,” ... Researchers found that while reductions in bacterial diversity start in the heavy pesticide use season of spring/summer, they remain low into the winter. SNAP Comment: The last allowed retail sale of Azinphos-methyl in Canada is dated on the label as 2011-12-31. Chlorpyrifos has also been found to cause dysbiosis in several areas of the digestive tract. There are still 29 Chlorpyrifos products registered in Canada. It is disappointing that studies take so long to be published. It is likely that other pesticides have the same effects. 

Parkinson's linked to gut bacteria  (Robert Ferris, CNBC, 1 December 2016) The scientists published their findings Thursday in the journal Cell. 'The germ-free mice were still overproducing alpha-synuclein, but their brain cells were not accumulating the protein. The germ-free mice showed fewer symptoms and performed better on a series of motor skills tests meant to model the kinds of tests given to human patients.' More experiments determined that what gut flora produces affects the development of Parkinson's. SNAP Comments: Several pesticides and other toxins have been linked to Parkinson's in the past. Now we also know from research that some pesticides, including glyphosate, affect the health of gut bacteria, usually suppressing good flora and promoting bad. The effects of a pesticide on gut flora are not required tests for pesticide registration. Of course use of antibiotics and what one eats is also important, but remember that people eating conventional food ingest several pesticides on a daily basis. Evidence is accumulating that gut flora is extremely important to the maintenance of health and the development of many diseases. I sincerely hope that more pesticide and toxins regularly found in our environment start being tested for their effect on gut flora. That research would provide a mechanism of action.

Microbiome

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Implications for Human Health: Pesticides and Other Environmental Contaminants Alter Gut Microbiome   (Beyond Pesticides, June 30, 2020) 'A review of scientific literature on the toxic effect of environmental contaminants—including pesticides—published in the journal Toxicological Science, “The Impact of Environmental Chemicals on the Gut Microbiome,” associates these chemicals to changes in the gut microbiome and other adverse health implications.    Multi-species evaluations find that various pesticides (i.e., insecticides, herbicides, and fungicides) alter the gut microbiome, lipid metabolism, and cause intestinal inflammation and oxidative stress. Specifically, the review mentions that exposure to pesticides glyphosate and chlorpyrifos, as well as other registered pesticides, increases anxiety and depression symptoms in mice, pathogenic bacteria in cattle, and inflammation and oxidative stress in the gut.'

Glyphosate and Roundup disrupt gut microbiome, contradicting regulator’s assumptions, study says (GM Watch,:December 11 2019) with link to original paper.  'The study in rats by an international team of scientists... has found that Roundup herbicide and its active ingredient glyphosate cause a dramatic increase in the levels of two substances, shikimic acid and 3-dehydroshikimic acid, in the gut, which are a direct indication that the EPSPS enzyme of the shikimic acid pathway has been severely inhibited.  In addition, the researchers found that both Roundup and glyphosate affected the microbiome at all dose levels tested, causing shifts in bacterial populations.  For the study, female rats (12 per group) were fed a daily dose of either glyphosate or a Roundup formulation approved in Europe, called MON 52276. Glyphosate and Roundup were administered via drinking water to give a glyphosate daily intake of 0.5 mg, 50 mg and 175 mg/kg body weight per day (mg/kg bw/day), which respigestive tract.microbiomeectively represent the EU acceptable daily intake (ADI), the EU no-observed adverse effect level (NOAEL), and the US NOAEL  The study found certain adverse effects at all doses tested, disproving regulators’ assumptions that these levels have no adverse effect.  Dr Antoniou said that the study has broken new ground in identifying the first ever biomarker of glyphosate exposure, which could be relevant to humans.  The study also revealed that Roundup, and to a lesser extent glyphosatedamaged the liver and kidneys of the rats, even over the relatively short study period of 90 days.' However, these changes were not reflected in blood chemistry.   ''Thus far, regulators have not incorporated these methods into the risk assessment process.'   SNAP COMMENT: Note the large difference between the EU and US no-observed adverse effect level (NOAEL). It illustrates the role of interpretation and lack of rigorous science when the US (and likely Canada) can have a 3 1/2 times higher NOAEL the the EU, presumably from the same background studies. And now, this study provides evidence that serious effects occur at those levels anyways,further illustrating.the severe limitations of basing approval of pesticides on regulatory studies only.

Toxic Herbicide Atrazine Causes Wasp Gut Microbiome to Develop Pesticide Resistance Across Generations  (Beyond Pesticides, February 11, 2020)   This study not only represents one of the first evolutionary studies on symbiont-mediated pesticide resistance, it also provides fodder for future research regarding the implications of exposure to xenobiotics (i.e., chemical substances like toxic pesticides foreign to an organism or ecosystem) for other gut bacteria hosts – such as honey bees and humans. Early generations of wasps in the study received a field-realistic dose of atrazine (300 ppb) or a subtoxic dose (30 ppb); exposed individuals showed a gut flora composition significantly different from the control group. The shift in microbiome composition persists across subsequent generations.   After the 8th generation of sublethal dosing, there was a significant increase in tolerance to atrazine. LC50 increased in later generations of the atrazine-exposed population, indicating pesticide resistance. The paper reads, “Our study is one of the few cases to experimentally evolve cooperation between a host animal and rare members of the microbiome to derive new fitness traits within the population.”   Even when wasps are switched to an atrazine-free diet for six generations, the bacterial composition was similar to that of the exposed parents. Overall, researchers observed an increase in microbiota diversity and bacterial load.'

also see pesticide fact sheets/malathion, atrazine, glyphosate,  Endocrine Disruption/disease

Pilot Study Links Celiac Disease to Long-Lived Endocrine Disrupting Chemicals, like DDT, in the Environment   (Beyond Pesticides, May 13, 2020)  'Considering previous studies on the deleterious impact of POPs on the immune system, scientists analyzed blood samples from 30 children and young adults (3-21) who had been recently diagnosed with celiac disease. They compared results to 60 other young people of similar demographics. The research focused on three chemicals: PBDE, DDE, and PFAS.   Researchers found a statistically significant association between DDE and celiac disease after adjusting for confounding factors. Children and young adults with higher blood levels of DDE were two times as likely to be newly diagnosed with celiac. The study found sex-specific PFAS associations among females, and some specific associations among males.'

New survey in humans shows link between advanced liver disease and glyphosate (GM Watch, 23 April 2019)  'The new study advances previous research led by Dr Michael Antoniou at King's College London. Dr Antoniou's team found that rats fed the glyphosate-based herbicide Roundup at very low levels within regulatory safety limits developed NAFLD and NASH over a long-term period of two years...Prof Mills' study does not prove that glyphosate actually causes liver disease. It is an "after the fact" study in humans with liver disease, in which exposure to glyphosate herbicide was not controlled but glyphosate excretion was measured after the subjects became ill. However, it does show a correlation between high glyphosate levels in human urine and NASH.'

Rats fed GM stacked-trait maize developed leaky stomachs  (GM Watch, 09 July 2018)  The study lasted twice as long as industry studies ( 6 months) and the control rats were fed a non-gmo diet. 'Drs Zdziarski and Carman said, "Joining together all the adverse findings into a single severity score, we found that the rats on the GM diet had a score that was 33% higher than rats on the non-GM diet. The changes we saw are closest to those seen with chemical gastropathy (also called reactive gastritis), caused by chemical irritants, such as aspirin, damaging the lining of the stomach."'    also filed under gmos /safety

Glyphosate Implicated in Fatty Liver Disease (Beyond Pesticides, January 11, 2017) Ultra-low doses of glyphosate formulations fed to rats is linked to an increased likelihood of developing non-alcoholic fatty liver disease (NAFLD), according to a recently published study in the journal Nature.

Kidney, Liver Damage Linked to Chronic, Low-Dose Glyphosate Exposure (Beyond Pesticides, September 1, 2015) 'Levels of exposure tested in the recent study are far below what EPA sets as the maximum contaminate level (MCL) in drinking water throughout the U.S. While rats in the study were chronically exposed to .1 parts per billion Roundup concentrations, EPA allows 700 parts per billion. The agency notes that “some people who drink water containing glyphosate in excess of the MCL over many years could experience problems with their kidneys or reproductive disorders.” ' More on glyphosate.

Glyphosate, pathways to modern diseases II: Celiac sprue and gluten intolerance
www.motherearthnews.comReview article. Interdiscip Toxicol. 2013; Vol. 6(4): 159–184.
doi: 10.2478/intox-2013-0026

Amidst Criticism, New Study Reveals GE Crops Inflame Digestive Tract (Beyond Pesticides, June 14, 2013) 

Pesticide exposure damages nervous system, brain and digestive tract