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Glyphosate (RoundUp)

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Glyphosate testing

Glyphosate Profile (Carex CanadaCAREX Canada   PESTICIDES – PROBABLE CARCINOGEN (IARC 2A)   (CARcinogen EXposure) is a multi-institution team of researchers and specialists with expertise in epidemiology, risk assessment, toxicology, geographic information systems, and knowledge mobilization. The purpose of CAREX Canada is to provide a body of knowledge about Canadians’ exposures to known and suspected carcinogens, in order to support organizations in prioritizing exposures and in developing targeted exposure reduction policies and programs. IARC Monograph on Glyphosate

Research Shows Adverse Impacts of Glyphosate on the Human Gut Microbiome   (Beyond Pesticides, April 30, 2021) A bioinformatics tool developed by researchers from the University of Turku in Finland indicates that “54% of species in the core human gut microbiome are sensitive to glyphosate.”  ...The researchers’ bioinformatic method categorizes EPSPS enzymes into four classes, each of which has a different sensitivity to glyphosate, with one of the four classes being particularly vulnerable.  In addition, the co-authors suggest that glyphosate may impact other metabolic pathways (beyond the Shikimate), positing that the mitochondria electron transport chain appears sensitive to the compound.

 Forestry Use of Glyphosate Reduces Fertility of Perennial Flowers and May Reduce Pollination     (Beyond Pesticides, June 22, 2021) 'Glyphosate herbicide use in forested areas persists in the environment for years and can prompt morphological changes in perennial flowers that reduce their fertility and may make them less attractive to pollinators. 

Glyphosate Raises Malaria Risk through Damage to Insect Immune Systems – New Study   (Sustainable Pulse, May 14 2021) with link to study.   'Melanin works in insect immunity essentially by trapping and killing an invading bacterium, fungal cell, or parasite. Melanin production rises in response to the infection, and in a process called melanization, melanin molecules surround the invading pathogen—while highly reactive molecules produced as part of the melanin-synthesis process, effectively destroy the invader. ...the researchers found that in A. gambiae mosquitoes, glyphosate inhibits melanin production and melanization, and thereby makes the mosquitoes more susceptible to infection by Plasmodium falciparum, the most dangerous species of malaria parasite. They found too that glyphosate alters the composition of the bacterial and fungal population in the mosquito midgut—the “gut microbiome” that, as in humans, helps regulate mosquito health.

Glyphosate-Based Herbicides and Sustainable Agriculture Do Not Mix!   (Beyond Pesticides, April 29, 2021) 'Glyphosate-based herbicides (GBHs) are incompatible with sustainable agriculture goals, according to a recent scientific literature analysis by scientists at Tufts University, Massachusetts.  However, studies demonstrate glyphosate is the main contributor to human, biotic, and ecosystem harms as toxicities from herbicides are now double what it was in 2004.   The National Academy of Sciences identifies four goals of sustainable agriculture—productivity, economics, environment, and social well-being for future generations. However, pesticides like glyphosate are ubiquitous in the environment, putting the health, economy, and food/resources for future generations at risk.

The main ingredient in RoundUp doesn’t just kill plants. It harms beetles, too.    Glyphosate seems to interrupt a key symbiotic relationship in sawtooth grain beetles.   (Philip Kieffer, Popular Science, May 13, 2021)    'But sawtooth grain beetles rely on a symbiotic relationship with a particular type of (unnamed) bacteria to build their shells. That bacteria in turn uses the shikimate pathway to manufacture the raw building blocks the beetles need.  Glyphosate appears to kill off those partners. After exposure to the chemical, the beetles make softer, weaker shells. It doesn’t kill them outright, but it leaves them more vulnerable. “They are doing way worse,” Engl says. “Their cuticle is thinner, and this is creating a higher risk of desiccation and higher mortality.”    The sawtoothed grain beetle is a crop pest, but Engl says it’s a model for all kinds of other beetles, which constitute about a quarter of all known animal species. “The beetle is generally used by us to understand the associations between insects, their microbial partners, and their ecological importance, so it’s a proxy for many insects,” Engl says.'

Endangered Florida Manatees Contaminated with Glyphosate/Roundup Due to Widespread Use   (Beyond Pesticides, March 30, 2021) Florida manatees are experiencing chronic glyphosate exposure that is likely to impact their immune system and make them more susceptible to other environmental stressors such as red tide and cold stress... Results found glyphosate in the bodies of 55.8% of Florida manatee samples. Most concerning, the amount of pesticide increased in a straight line over the course of the study.  Authors of the study indicate that it is appropriate to consider glyphosate a “pseudo-persistent” pollutant, “in which new applications of the herbicide replace the molecules that are being removed,” the study reads.'

Implications for Human Health: Glyphosate-Related Soil Erosion Re-Releases Toxic Pesticides from Soil   French West Indies study.  (Beyond Pesticides, March 4, 2021) A new study finds glyphosate use stimulates soil erosion responsible for releasing banned, toxic pesticide chlordecone (Kepone), which was used in banana production. ... Researchers note, “Chlordecone fluxes drastically increased when glyphosate use began, leading to widespread ecosystem contamination. As glyphosate is used globally, ecotoxicological risk management strategies should consider how its application affects persistent pesticide storage in soils, transfer dynamics, and widespread contamination.” Conventional pesticide use contaminates soil and their respective Critical Zone (CZ) compartments.  SNAP Comment: I wonder how many other chemicals it might release through erosion... However, there was a lot more soil drifting in SK before chem fallowing with Roundup.

Economic Impact of Glyphosate Contamination on Organic Production in Saskatchewan (COTA Organic summit, November 18. 2019)

  1. 26% producers had an unintended contact with glyphosate incident on their farm
  2. 46% of respondents had to take land out of production
  3. 20% of respondents lost a sale
  4. 52% of respondents reported a financial loss
  5. 20 % of exporters had loads rejected by buyer that had passed glyphosate residue testing before it left Saskatchewan.

Glyphosate and Other Weed Killers Create Antibiotic Resistant Bacteria in Agricultural Soils   (Beyond Pesticides, February 24, 2021) 'Soil sprayed with weedkillers glyphosateglufosinate, or dicamba are likely to contain higher amounts of antibiotic resistant bacteria, according to research published earlier this month in the journal Molecular Biology and Evolution. Each year in the United States, at least 2 million people develop an antibiotic resistant infection, and over 23,000 die. Authors of the study say widespread herbicide use is likely playing a role. “Our results suggest that the use of herbicides could indirectly drive antibiotic resistance evolution in agricultural soil microbiomes, which are repeatedly exposed to herbicides during weed control,” said Ville Friman, PhD of the University of York in the United Kingdom.   Contrary to the pesticide industry’s claim that these chemicals break down quickly and become inert by binding to soil particles, large proportions of the herbicides remained in the soil at the end of the 60-day experiment, stemming back from the first application. For glyphosate 18% remained, glufosinate 21%, and dicamba 34%.  .. scientists determined that herbicide exposure triggers evolutionary pressures on bacteria similar to those exposed to antibiotics...  “Interestingly, antibiotic resistance genes were favoured at herbicide concentrations that were not lethal to bacteria,” said Dr. Friman. “This shows that already very low levels of herbicides could significantly change the genetic composition of soil bacterial populations. Such effects are currently missed by ecotoxicological risk assessments, which do not consider evolutionary consequences of prolonged chemical application at the level of microbial communities.”    'The field '(s)amples matched up closely to the results of the microcosm experiment:'

In Cahoots with Pesticide Industry, Former U.S. Officials Try to Stop Mexico from Banning Glyphosate, But Fail  (Beyond Pesticides, February 17, 2021) 'New details are emerging around the pressure campaign Mexican President Andrés Manuel López Obrador and his administration withstood as the country moved towards banning Bayer/Monsanto’s glyphosate (Roundup) herbicide. According to documents obtained by a Freedom of Information Act request and published in the Guardian, U.S. Trade Representative, the U.S. Environmental Protection Agency (EPA), and U.S. Department of Agriculture (USDA) worked in coordination with Bayer/Monsanto and the agrichemical industry umbrella group Croplife America to stop the Mexican government from embracing a precautionary approach to pesticide regulation. While the Trump administration and its collaborators were successful in a similar campaign against Thailand, there are no indications that Mexico will rescind its final decision to ban glyphosate, made at the end of last year.' 

Long-Term Roundup Exposure Found to Harm Keystone Wildlife Species   (Beyond Pesticides, January 6, 2021)  “The problem is that much of the evidence is rooted in outdated toxicity tests which only look at the number of animals that die on exposure to extremely high concentrations of these chemicals,” Dr. Orsini said. “These tests also overlook the pathological effects arising from long-term exposure to low doses. What we’re proposing is that toxicity is measured by looking at what happens to the animal at a molecular and fitness level following long-term exposure, which encompasses the entire animal life cycle.”   Changes in fitness were seen for every trait except mortality. Roundup delayed average age of sexual/reproductive maturity, reduced size at maturity, decreased the total number of offspring produced, and increased developmental failure – as determined by the number of aborted eggs, and juveniles borne dead..  Researchers also observed damage to DNA, with glyphosate and Roundup showing only slight differences in affected pathways      Roundup and glyphosate were also found to indirectly alter both the makeup and total number of microbiota in the water flea’s gut. These changes were correlated with alterations to the way fat and carbon are metabolized, as well as the animal’s detoxification pathways.

Ubiquitous Herbicide Glyphosate/Roundup Threatens Nearly All Endangered Species, Says EPA   (Beyond Pesticides, December 4, 2020) From the 'release of the Environmental Protection Agency’s (EPA’s) draft biological evaluation (BE) of glyphosate. The assessment indicates that use of this ubiquitous herbicide likely threatens nearly every animal and plant species on the U.S. list of threatened and endangered species — 93% of them, in fact. “No NE (No Effect) determinations were made for any species or designated critical habitats; therefore, all species received a MA ( May Affect) determination.” Thus, all species and habitats underwent the second step: NLAA (Not Likely to Adversely Affect) determinations were made for 119 species and 33 species’ critical habitats, and LAA (Likely to Adversely Affect) determinations were made for 1,676 species and 759 critical habitats. For the LAAs, 96% of species and 97% of habitats had moderate evidence; strongest evidence was found for less than 1% of both species and habitats; and weakest evidence was found for 4% of species and 3% of critical habitats. The review (of glyphosate) began in 2009, has already taken 11 years, without a full assessment of the widespread harmful impacts on people and the environment in that time period.” More specifically, plaintiffs charged EPA with bias, ignoring and using incomplete scientific data, and delay in finishing “any assessment of glyphosate’s impacts on thousands of potentially harmed endangered species, delaying it until a future decision.”  As of the January 2020 interim decision, what remained to be completed before a final reregistration decision were evaluations of (1) the risks of glyphosate exposure to endangered species, and (2) screenings for endocrine system impacts. This biological evaluation goes to the first of those outstanding items.

Aminomethylphosphonic acid alters amphibian embryonic development at environmental concentrations  (Environmental Research, Volume 190, November 2020, MarionCheron,FrançoisBrischoux)   Environmentally relevant concentrations of AMPA (the main metabolite of glyphosate) have been found to affect embryonic survival, development duration and hatchling morphology in spined toads. Non-linear concentration response patterns were likely to occur at low concentrations, meaning that the effect did not increase with the dose – greater effects were found at low concentrations of AMPA than higher levels. The study concluded that regulatory decision-making needs to go beyond the use of high-dose studies to identify official no-effect concentrations.'     'Our experimental concentrations of AMPA were 100–6000 times lower than official Predicted-No-Effect-Concentrations. We found that these low-level concentrations of AMPA decreased embryonic survival, increased development duration and influenced hatchling morphology.'

Glyphosate in chicken poop used as fertilizer is hurting food production, researchers say   (US Right to Know, September 9, 2020 by Carey Gillam) '  Because there are glyphosate residues in human and animal food, detectable glyphosate levels are commonly found in human urine and animal manure.  'These glyphosate residues in fertilizer are a problem for growers for many reasons, according to the Finland researchers. “We found that poultry manure can accumulate high residues of (glyphosate-based herbicides), decrease plant growth and reproduction, and thus inhibit the growth-promoting effects of manure when applied as fertilizer,” the paper states. “These results demonstrate that the residues pass through the digestive process of birds, and more importantly, they persist in the manure fertilizer over long periods.” The researchers said the glyphosate residues can persist in ecological systems, affecting several non-target organisms over many years.'

Facts and Fallacies in the Debate on Glyphosate Toxicity (Robin Mesnage and Michael N. Antoniou, Frontiers in Public Health, Perspective, 24 November 2017)    'Thus, the mechanisms and vast range of conditions proposed to result from glyphosate toxicity presented by Samsel and Seneff in their commentaries are at best unsubstantiated theories, speculations, or simply incorrect. This misrepresentation of glyphosate’s toxicity misleads the public, the scientific community, and regulators. Although evidence exists that glyphosate-based herbicides are toxic below regulatory set safety limits, the arguments of Samsel and Seneff largely serve to distract rather than to give a rational direction to much needed future research investigating the toxicity of these pesticides, especially at levels of ingestion that are typical for human populations.'    SNAP Comment: Hopefully the studies recommended here will be condicted to enlighten the debate.

Study Shows Organic Food Diet Reduces Residues of Glyphosate in Body   (Beyond Pesticides, August 13, 2020) 'Levels of the notorious herbicide compound glyphosate in the human body are reduced by 70% through a one-week switch to an organic diet.'

Glyphosate in Roundup Linked to Parkinson’s Disease (Beyond Pesticides, May 15, 2020) The ubiquity of glyphosate use in agriculture — which leaves residues of the toxic chemical in food — may mean that exposures to it represent a significant risk factor for the disease. Glyphosate is already implicated or proved in the development of numerous health anomalies, including cancer.  They found that exposures to glyphosate in adult mice intensified a type of neurotoxicity associated with PD. The abstract for the research paper, titled “Glyphosate exposure exacerbates the dopaminergic neurotoxicity in the mouse brain after repeated administration of MTPT,” is available online; once published, the paper will be available through Science Direct.   The researchers found that the exposures to glyphosate exacerbated the reduction of DAT (dopamine transporter) immunoreactivity in the striatum, and the reduction of TH (tyrosine hydroxylase) positive cells in the SNr after MPTP administration. Translation: the exposure to glyphosate appears both to worsen the ability of local neurons (in the SNr and striatum) to produce and transport dopamine effectively, and to intensify the neurotoxicity of other extrinsic chemicals (in this case, MPTP).

Glyphosate and Roundup proven to disrupt gut microbiome by inhibiting shikimate pathway (GM Watch, 11 December 2019) 'The study found certain adverse effects at all doses tested, disproving regulators' assumptions that these levels have no adverse effects.' SNAP Comment: Note the huge variation in study dosage, based on regulatory acceptable levels. Clearly, glyphosate and Roundup are not 'safe' at levels considered acceptable daily intake or 'no adverse effects'. Interesting that in most pesticide studies there are liver and/or kidney effects. After all, these organs are two of the main detoxification organs in the body. The issue with our 'dose makes the poison' based regulatory system is that we then divide the dose causing problems by 1000 or something then assume it's OK at that level. This is clearly 'baloney'. 'However, proof that glyphosate herbicides can inhibit the EPSPS enzyme and the shikimate pathway in gut bacteria has been lacking. But a new study has proven beyond doubt that this does indeed happen. The study in rats has found that Roundup herbicide and its active ingredient glyphosate cause a dramatic increase in the levels of two substances, shikimic acid and 3-dehydroshikimic acid, in the gut, which are a direct indication that the EPSPS enzyme of the shikimic acid pathway has been severely inhibited. In addition, the researchers found that both Roundup and glyphosate affected the microbiome at all dose levels tested, causing shifts in bacterial populations. For the study, female rats (12 per group) were fed a daily dose of either glyphosate or a Roundup formulation approved in Europe, called MON 52276Glyphosate and Roundup were administered via drinking water to give a glyphosate daily intake of 0.5 mg, 50 mg and 175 mg/kg body weight per day (mg/kg bw/day), which respectively represent the EU acceptable daily intake (ADI), the EU no-observed adverse effect level (NOAEL), and the US NOAEL.' 'The study also revealed that Roundup, and to a lesser extent glyphosate, damaged the liver and kidneys of the rats, even over the relatively short study period of 90 days' .with little reflected in the blood biochemistry. 'Histopathological (microscopic) examination of the liver showed that the two higher doses of Roundup caused a statistically significant and dose-dependent increase in lesions, fatty liver disease changes, and necrosis (death of tissue). In contrast, none of the control animals showed the same liver effects.'

Glyphosate decreases mycorrhizal colonization and affects plant-soil feedback (Marjo Helander et al, Science of The Total Environment,Volume 642, 15 November 2018, Pages 285-291)  Highlights

  • In northern ecosystems glyphosate residues are detected in crop plants the following growing season.
  •  Arbuscular mycorrhizal colonization is decreased in glyphosate treated plants.
  • The magnitude of mycorrhizal reduction is dependent on tilling and soil history.

The Pesticide Generation   Children on the Front Line  (Webdoc.France24.com,original FRANCE 24 multimedia documentary has been translated from the original in French, 2019)  A court case against glyphosate and what is happening in France about banning glyphosate. "The medical community is unambiguous: Théo’s malformations are not genetic, but definitely linked to an external factor. “Right from birth, Théo’s doctors pointed a finger at pesticides,” says Sabine, who at the time didn’t make an immediate connection to the weed killer that she used at home to spray the horse paddock. “The wake-up call came later,” she remembers. In August 2008, to be precise. Just as she did every year at the same time, Sabine treated the area with Glyper, a herbicide containing glyphosate. “It suddenly hit me; I remembered what the surgeon had told me about pesticides.” Due to the teratogenic risks of glyphosate causing malformation of embryos and foetal abnormalities cited in scientific studies, doctors say the link to Théo’s birth defects is “highly likely”. “I was exposed to glyphosate at a crucial moment in my pregnancy – during the first four weeks,” she says. “I didn’t even know I was pregnant, so I didn’t take any particular precautions.'

New study finds glyphosate causes disease across several generations   (The Organic and non-GMO Report, May 2, 2019)    "But writing in the journal Scientific Reports, the researchers say they saw “dramatic increases” in several pathologies affecting the second and third generations. The second generation had “significant increases” in testis, ovary, and mammary gland diseases, as well as obesity. In third-generation males, the researchers saw a 30 percent increase in prostate disease—three times that of a control population. The third generation of females had a 40 percent increase in kidney disease, or four times that of the controls.  More than one-third of the second-generation mothers had unsuccessful pregnancies, with most of those affected dying. Two out of five males and females in the third generation were obese."

Health and Environmental Groups Call on EPA to Revoke Glyphosate’s Registration  (Beyond Pesticides, September 4, 2019) Sixteen organizations representing health, environmental, farmer, and farmworker communities joined together yesterday to call on EPA to remove glyphosate from the marketplace. The groups cite a combination of high-profile lawsuits, environmental impacts, increasing reports of weed resistance, and growing public concern over the health effects of glyphosate in their comments on EPA’s interim reregistration review decision for the chemical. The comments warn that EPA is at risk of damaging the public’s trust in the agency’s review process for toxic pesticides. The article also ' replies to EPA’s attacks against the World Health Organization’s International Agency for Research on Cancer (IARC).

Unique Hair Testing Project Reveals High Levels of Glyphosate in Members of the Japanese Parliament (Sustainable Pulse, Aug 29 2019)   'The Detox Project’s Director, Henry Rowlands, stated Thursday; “This unique testing project was made possible by the development of new hair testing methods that have enabled our long-term exposure to pesticides to be identified for the first time. Urine and blood testing only give us a very short-term picture of exposure, whereas hair testing gives us the real and full picture of what we have been exposed to over the long-term and thus what we need to avoid.”'  'From the 28 hair samples taken 75% of them tested positive for long-term pesticide exposure, with a total of 14 pesticides being detected.'   'The pesticides detected included Cyprodinil, Fipronil Sulfone, Iprovalicarb, Metolachlor, Propiconazole, Pyraclostrobin, Spiroxamine, Tebuconazole, Tetramethrin, Transfluthrin, Trifloxystrobin, Glyphosate, AMPA, Glufosinate.' out of 60 tested for. 'Four of those pesticides were found in over 10% of the samplesTebuconazole ( a fungicide) – 10.7%, Transfluthrin (an insecticide) – 14.3 %, Glyphosate (a herbicide) – 32.1%, AMPA (the main metabolite of glyphosate) – 53.6%'   'The results for glyphosate and AMPA included regular levels of over 33 and 166 ppb respectively with the highest results of 791 ppb for glyphosate and 1205 ppb for AMPA.'  ''The Japanese Ministry of Agriculture, Forestry and Fisheries reported that 90% of U.S. wheat imports and an even higher % of Canadian wheat imports contain glyphosate residues, mainly due to the practice of pre-harvest spraying'

Glyphosate: Destructor of Human Health and Biodiversity   Another Silent Killer (Compiled by Rosemary Mason MB ChB FRCA with information from a global network of independent scientists, toxicologists, beekeepers, environmentalists, Governments, Industry and Regulators)   Article received by Tony Mitra from Dr. Rosemary Mason of UK. He says: "The article is available on Academia.edu for free for members. I am not a member, but got a free copy from her. I decided to include this 53 page pdf document as a downloadable file for anyone interested on my site.

Glyphosate-based herbicide exposure during pregnancy and lactation malprograms the male reproductive morphofunction in F1 offspring   (Jakeline Liara Teleken et al, Published online by Cambridge University Press: 16 July 2019)   'data indicate that maternal exposure to glyphosate-ROUNDUP® during pregnancy and lactation may lead to decreased spermatogenesis and disruptions in hypothalamus–pituitary–testicular axis regulation in F1 offspring.' Link to scientific study abstract and references. 

Don Huber - Glyphosate - Dangers and Soil Remediation (Global Earth Repair conference, May 9, 2019)  Don Huber goes through all the dangers of this defoliant and toxin, why it is so deadly, and how to remove it from bodies and from soil Thank you for your work, Don!!   Over 1 hour video well worth watching. As usual, Huber presents  lots of studies in many fields. Widespread use and history of use, as well EPA 'acceptable levels' in foods being much higher than the levels observed to cause health issue in the lab and in real life. Interesting that when glyphosate replaces glycine in proteins, it causes proteins to fold wrong and adopt a shape characteristic of prion diseases like mad cow diseaseGlyphosate is antibiotic against the good bacteria but, unfortunately, the bad ones (Salamonella.E coli, Clostridium, etc) are resistant. Also presents studies indicating that supplementing bees in areas of severe bee hive loss with water containing minerals and some probiotics can reduce the hive loss from 40%/year to .05%. Part of the solution for livestock diseases is to buy clean feed and supplement minerals. Lots of data from many sources build the case against glyphosate.

Roundup’s Risks Could Go Well Beyond Cancer   Evidence of the cheap herbicide’s danger to biological functions and the environment continues to mount. Why are U.S. regulators not listening?  (By Mark Buchanan, Bloomberg Opinion, June 4, 2019)  'Both the EPA and the EFSA relied on information provided by researchers linked to the industry and considered studies provided by the industry that were not peer-reviewed or made public. The IARC relied solely on publicly available peer-reviewed research.'  ' In both the U.S. and Europe, the supposedly safe limits for human ingestion are based on long-outdated science. Research also points to serious adverse consequences for the environment, and there are indications glyphosate can cause disease in mammals even several generations removed from the initial exposure.'   SNAP comment: The article does not answer its question other than pointing out the narrow scope of studies which regulatory agencies evaluate. I can add the mandatory 'risk-benefit assessment' where use is considered a benefit and need and trumps any negative health and environmental effects. This, in my view, is 'long outdated science', as well as the belief that there is a 'safe' dose at which there is no effect, and the unscientific way this is calculated. 

Assessment of Glyphosate Induced Epigenetic Transgenerational Inheritance of Pathologies and Sperm Epimutations: Generational Toxicology (Scientific Reports | (2019) 9:6372   scientific paper. 'Therefore, we propose glyphosate can induce the transgenerational inheritance of disease and germline (e.g. sperm) epimutations. Observations suggest the generational toxicology of glyphosate needs to be considered in the disease etiology of future generations.'

U.S. Health Agency Concurs with International Findings Linking Weed Killer Glyphosate to Cancer, while Inspector General Investigates Misconduct at EPA   (Beyond Pesticides, April 23, 2019)   'But despite the attempts of an apparently corrupt EPA official, earlier this month DHHS’ Agency for Toxic Substances and Disease Registry (ATSDR) released its first draft on the Toxicological Profile for Glyphosate. Top-line findings appear consistent with conclusions made by the World Health Organization’s International Agency for Research on Cancer (IARC) on the carcinogenicity of glyphosate...However, the studies and references analyzed in the report indicate clearly there is strong link between glyphosate and cancer. Of particular note are the three meta-analyses of epidemiological studies reviewed by ATSDR: Schinasi and Leon (2014), Chang and Delzell (2016), and the IARC monograph, which all found “positive associations” between glyphosate exposure and cancer. The Chang and Delzell (2016) study, funded in part by Monsanto itself, downplays in its abstract conclusions that in fact line up closely to the other meta-studies.'

Another Study Links Glyphosate to Cancer  also a link to study. (Beyond Pesticides, March 26, 2019) 'In a study investigating the carcinogenic effects of pesticide exposure by analyzing data on 316,270 farmers and farmworkers in the U.S., Norway, and France, researchers have identified elevated risk for non Hodgkin lymphoma (NHL) and some subtypes, linking glyphosate and large B-cell lymphoma. Other pesticides linked to the disease include the pyrethroid deltamethrin and chronic lymphocytic leukemia/small lymphocytic lymphoma; and terbufos and NHL overall.'  'For this research, chemical groups and active ingredients were selected based on common use in at least two of the three countries. In addition, researchers gave priority to chemical groups and active ingredients for which some associative evidence with lympho-hematological malignancies has already been established, and to active ingredients not previously investigated in epidemiological studies. Glyphosate and dicamba were included in the study, as well as these categorical compounds: four insecticides (organophosphates, organochlorines, carbamates, and pyrethroids); seven herbicides (phenyl ureas, chloroacetanilides, dinitroanilines, phenoxys, thiocarbamates, triazines, and triazinones); two fungicides (dithiocarbamates and phthalimides); and arsenical compounds.

European Court of Justice Orders EU Regulators to Publicly Release Secret Industry Glyphosate Studies (Organic Consumer Association, March 7, 2019)   'The General Court concludes that the requested studies must be regarded as constituting information which ‘relates to emissions into the environment’ and that an overriding public interest in disclosing the studies is deemed to exist. EFSA could not therefore refuse to disclose them on the ground that that would have an adverse effect on the protection of the commercial interests of the owners of the requested studies.'   Original document at:

EFSA’s decisions refusing access to the toxicity and carcinogenicity studies on the active substance glyphosate are annulled

General Court of the European Union
Luxembourg, 7 March 2019
Judgment in Cases T-716/14
Anthony C. Tweedale v European Food Safety Agency
(EFSA) and T-329/17 Hautala and Others v EFSA

A Pesticide Distributor, an Insurance Company, a Major City, and a Scientific Study Nix Glyphosate (Roundup)  (Beyond Pesticides, March 15, 2019) . 'First up: Harrell’s is a company that sells chemical pesticides, synthetic fertilizers, and “adjuvants and colorants,” among other products, primarily to golf courses, and to the horticulture-nursery, turf, and landscape sectors. The company announced on March 11 that it stopped selling products containing glyphosate as of March 1, 2019 because neither its current insurance company nor others the company consulted would underwrite coverage for the company for any glyphosate-related claims.'  SNAP Comment: Perhaps the Canadian insurance industry should get on that too.... seems like what a government refuses to do (ban a problematic product) can be achieved by the insurance industry without any backlash.

Study Confirms Findings on Carcinogenic Glyphosate, Suggests “Compelling Link”  (Beyond Pesticides, February 28, 2019)  Statistical analysis revealed there to be a 41% increased risk of NHL resulting from high exposure to glyphosate-based herbicides. To compare and add weight to their results, researchers also conducted a second statistical analysis using older (2005) AHS data, which surprisingly revealed a higher, 45% risk.

The herbicide glyphosate persists in wild, edible plants: B.C. study (RANDY SHORE, Vancouver Sun, February 20, 2019)  'Wood found unexpected levels of glyphosate in new shoots and berries of plants that survived an aerial herbicide application made one year earlier... The 10 species tested were selected for their importance as traditional-use plants, because some First Nations had expressed concerns about the long-term effects of glyphosate on wild plants, said Wood...Glyphosate is typically broken down in soil by microorganisms over a period of months, but how long it persists in living plant tissues is unknown, she said.'

Exposure to Glyphosate-Based Herbicides and Risk for Non-Hodgkin Lymphoma: A Meta-Analysis and Supporting Evidence (Mutation Research/Reviews in Mutation Research, Available online 10 February 2019)   'Overall, in accordance with evidence from experimental animal and mechanistic studies, our current meta-analysis of human epidemiological studies suggests a compelling link between exposures to GBHs and increased risk for NHL.'

Glyphosate is Genotoxic to Human White Blood Cells at Low Concentrations  (By Henry Rowlands, GMO Evidence, October 24th, 2018)  link to full paper.  'Human lymphocytes were exposed to five glyphosate concentrations: 0.500, 0.100, 0.050, 0.025, and 0.0125 μg/mL, where 0.500 μg/mL represents the established acceptable daily intake value, and the other concentrations were tested in order to establish the genotoxicity threshold for this compound. We observed that chromosomal aberration (CA) and micronuclei (MNi) frequencies significantly increased at all tested concentrations, with exception of 0.0125 μg/mL.'

Glyphosate perturbs the gut microbiota of honey bees  (Erick V. S. Motta, Kasie Raymann, and Nancy A. Moran, PNAS October 9, 2018 115 (41) 10305-10310) complete sccientific paper. 'The honey bee gut microbiota is dominated by eight bacterial species that promote weight gain and reduce pathogen susceptibility. The gene encoding EPSPS is present in almost all sequenced genomes of bee gut bacteria, indicating that they are potentially susceptible to glyphosateWe demonstrated that the relative and absolute abundances of dominant gut microbiota species are decreased in bees exposed to glyphosate at concentrations documented in the environment.

“Safe Levels” Of Exposure Don’t Exist When It Comes To Monsanto’s Glyphosate Poison (The Ring of Fire, Dec 16, 2018)  Interesting and accurate video on the state of research on glyphosate. 'The main ingredient in Monsanto’s Roundup, glyphosate, is not safe, even at levels that the EPA is telling us is safe. Mike Papanotnio and Farron cousins discuss'. SNAP comment: Technically, neither the EPA or the PMRA can say a pesticide is 'safe" because all registered products are designed to kill. What they determine through LD50 (the dose that kills 1/2 fo the animals) put through some equations, is an acceptable dose i.e.a dose at which they don't think negative health effects will occur. Another issue with re-evaluation of pesticide is the people chosen to sit on the re-evaluation committees, many of whom have a long history of contracting with pesticide companies to do 'regulatory science'. The case of 2,4-D re-evaluation for home use in Canada (2005) illustrates that. The committee was formed of 2 industry-related 'experts', 1 PMRA official and 2 epidemiologsts. Studies of cancer in dogs were eliminated, and the cancer ones minimized so it remained on the Canadian market. The pesticide industry previously unsuccessfully tried to re-write the book on epidemiology so the burden of proof would be so high that all studies would be negative. Regulatory pesticide testing was designed decades ago and has not kept up with the science of low dose and endocrine effects so is totally meaningless in that regards.

Glyphosate Monograph (PAN, 2016) seems like the most up to date compendium of information.

Brazil: Glyphosate found in over 80% of breast milk samples  (GM Watch, 11 August 2018)  'Surprisingly, the same contamination level was detected in the municipality of Oeiras, roughly 750 kilometers from the Urucui, where agricultural activity is the least in the state. also filed at pesticides and food 

Glyphosate study shows adverse health effects at "safe" dose  (GM Watch, 16 May 2018) 'The study was focused on the newborn, infancy and adolescence phases of life. The results reveal that glyphosate-based herbicide (GBH) was able to alter certain important biological parameters, mainly relating to sexual development, genotoxicity, and the intestinal microbiome....The effects occurred at a dose deemed safe by regulators to ingest on a daily basis over a long-term period. In human-equivalent terms the dosing period corresponded to the period from the embryo stage to 18 years of age.' The levels measured in urine suggest 'a bioaccumulation effect of glyphosate that was proportional to the length of treatment.'  also filed under microbiota changes 

New study links common herbicides and antibiotic resistance  (University of Canterbury,October 12, 2018)    'A new study finds that bacteria develop antibiotic resistance up to 100,000 times faster when exposed to the world's most widely used herbicides, Roundup (glyphosate) and Kamba (dicamba) and antibiotics compared to without the herbicide.'   Also filed under  drug interactions

Common Weed Killer Linked to Bee Deaths  (University of Texas news, Sept. 24, 2018)  "The researchers exposed honey bees to glyphosate at levels known to occur in crop fields, yards and roadsides. The researchers painted the bees’ backs with colored dots so they could be tracked and later recaptured. Three days later, they observed that the herbicide significantly reduced healthy gut microbiota. Of eight dominant species of healthy bacteria in the exposed bees, four were found to be less abundant. The hardest hit bacterial species, Snodgrassella alvi, is a critical microbe that helps bees process food and defend against pathogens...The bees with impaired gut microbiomes also were far more likely to die when later exposed to an opportunistic pathogen, Serratia marcescens, compared with bees with healthy guts. Serratia is a widespread opportunistic pathogen that infects bees around the world."  Also see  Study: Roundup Weed Killer Could Be Linked To Widespread Bee Deaths  (Vanessa Romo, NPR, September 25, 2018) 

Dramatic postmortem evidence of glyphosate-linked damage to animal organs (Renewable Farming LCC WakeUP)  Sept. 17, 2017 -- We encourage you to study the web posting by Dr. Dupmeier at this link. It takes you to his "DOCTORTED" website. This practicing veterinariam's report was posted July 17, 2017 and soon "went viral." His video presentation is called Without Prejudice - Glyphosate, in which he presents evidence of health damage to amimals by glyphosate and how changing feed and adding molasses can correct problems. Researcher Judy Carman is the principal author of the scientific report, which reveals essentially the same GMO/glyphosate consequences seen by Dr. Dupmeier. This article links to Dr. Carman's site, which contains that entire study plus more.

Glyphosate-based Herbicide Impairs Female Fertility - new study (GM Watch 24 July 2018.)  What the 3 month studies mandated by regulatory agencies cannot show:  The dosages were selected based of the reference dose (dose supposed to be safe over a lifetime) and the higher dose was 1/5th of the "industry-declared no-observed adverse effect level (NOAEL)". 'However, although all glyphosate herbicide-exposed first generation female rats became pregnant, they had a lower number of implantation sites of fertilized eggs, compared with controlsThe second generation offspring from both glyphosate herbicide-exposed groups showed delayed growth, evidenced by lower foetal weight and length, and a higher incidence of abnormally small foetuses...Also, to the authors' surprise, malformations (conjoined foetuses and abnormally developed limbs) were detected in the second generation of offspring from the higher dose of glyphosate herbicide group...The findings of malformations reflect epidemiological findings that people living in an Argentine town in the heart of the GM soy and maize growing area, where glyphosate-based herbicides are sprayed in large amounts, suffer birth defects at twice the national average average rate.' Link to original study and others.  

Press Release: New Study: Glyphosate persists! And European top soils are contaminated with it. (PAN Europe, October 13, 2017)  "45% of Europe’s top soil contains glyphosate residues, demonstrating the over-reliance of the EU agricultural model on this harmful herbicide chemical. In contrast to what its manufactures2 purport, glyphosate persists in soils affecting not only soil fertility and crop quality, but also human and environmental health."   "The concentrations of glyphosate and AMPA found in the study have been shown to be toxic to soil organisms such as earthworms3, beneficial bacteria4 and fungi5 , as glyphosate weakens down plants’ natural defences making them susceptible to pathogens6." 

Glyphosate on feed affects livestock: vet (Western Producer, 19 October 2017)  A veterinarian in Shaunavon, Sask., believes feed with glyphosate residue adversely affects cattle health. Dr. Ted Dupmeier, who operates h